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Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

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The World Health Organization (W.H.O). defines oral potentially malignant disorders (OPMDs) as "A histologically proven lesion that is associated with a significantly increased risk of malignant transformation."Oral leukoplakia is the most commonly occurring oral potentially malignant disorder.

Impact of Treatment of Obstructive Sleep Apnea Syndrome by Continuous Positive Airway Pressure Equipment at Night on the Lower Urinary Tract Symptoms and the Erectile Dysfunction

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Obstructive sleep apnea syndrome (OSAS) is the most common nocturnal breathing disorder. It is characterized by the occurrence, during sleep, of repeated episodes of complete collapse (apnea) or incomplete (hypopneas) of the upper airways. OSAS is a pathology that, through its cardiovascular and

Interrelation Between Bronchial Asthma and Smoking

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The mechanisms by which cigarette smoking contributes to disease severity in asthma are incompletely understood, but it has been suggested that cigarette smoking may change inflammation and airway remodelling in asthma to become more similar to that in COPD (chronic obstructive pulmonary

Use of Single Staged Nasolabial Flap in Oral Submucous Fibrosis

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The world of medical science is replete with a plethora of conditions both physiological and pathological which exhibit manifold symptoms, some of which man has conquered while against others, he is still waging a relentless battle. In this fast changing world of stress and cut throat competition,

Progesterone Augmentation of Nicotine Replacement Therapy Study

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This study seeks to determine if modifying the hormonal milieu of the menstrual cycle, through administration of exogenous progesterone, will improve the effectiveness of treatments for smoking cessation in women. Progesterone, a gonadal hormone, is used clinically for treatment of endometrial

Cardiovascular Risk Profile in Patients With Congenital Adrenal Hyperplasia

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Treatment with glucocorticoids and mineralocorticoids has changed congenital adrenal hyperplasia (CAH) from a fatal to a chronic lifelong disease. Long-term treatment, in particular the chronic (over-)treatment with glucocorticoids, may have an adverse effect on the cardiovascular risk profile in

Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery

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Obesity is defined qualitatively by the World Health Organization, is "abnormal or excessive fat accumulation that may impair health. Obesity is now estimated to lead to 280,000 deaths each year in the U.S., making it the second most common cause of preventable death only behind tobacco[1]. Obesity

Pioglitazone for Oral Premalignant Lesions

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PRIMARY OBJECTIVES: I. To determine the clinical and histologic response of oral premalignant lesions to 24 weeks of therapy with pioglitazone, 45 mg once daily (qd), defined as 50% or greater reduction in the sum of all measured products of perpendicular dimensions of target lesions, or improvement

Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction

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Smoking is the largest risk factor for the development of COPD. It has been shown in patients with COPD that smoking induces airway inflammation characterized by bronchial infiltration of neutrophils, macrophages, lymphocytes and mast cells. In addition, smoking accelerates lung function loss and

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