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The effect of hypothermia on biochemical and morphological aspects of carbon tetrachloride hepatotoxicity.

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The temporal relationships among selected correlates of hepatocellular damage were investigated in cordotomized, hypothermic rats intoxicated with carbon tetrachloride (CCl4). Rats were spinally transected between C6 and C7 and allowed to become hypothermic. CCl4 (1.25 ml/kg ip) was administered as

Depression of the photic after discharge of flash evoked potentials by physostigmine, carbaryl and propoxur, and the relationship to inhibition of brain cholinesterase.

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The effects of N-methyl carbamate pesticides on the photic after discharge (PhAD) of flash evoked potentials (FEPs) and the relationship between inhibition of brain cholinesterase (ChE) activity and the PhAD were evaluated. FEPs were recorded in Long Evans rats treated with physostigmine (s.c.) 0,

Influence of gender on thermoregulation and cholinesterase inhibition in the long-evans rat exposed to diazinon.

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Diazinon is an organophosphate (OP)-based, anticholinesterase insecticide that irreversibly inhibits acetylcholinesterase activity and produces cholinergic stimulation in central nervous system (CNS) and peripheral tissues. Our laboratory has found that OPs administered orally in rats induce a

Exposure to a high-fat diet decreases sensitivity to Δ9-tetrahydrocannabinol-induced motor effects in female rats.

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Arachidonic acid, a fatty acid component of neuronal cell membranes, forms the backbone of endogenous ligands of the endocannabinoid system. The lipid nature of this system may make it particularly susceptible to changes in fat content of the diet, which may, in turn, affect endocannabinoid tone and

Chlordecone-induced effects on thermoregulatory processes in the rat.

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To investigate the mechanism(s) involved in chlordecone (CLD)-induced hypothermia, we examined colonic (Tcol) and tail skin (Tsk) temperatures, preferred ambient temperature (Ta), evaporative water loss, and metabolic rate following CLD exposure in the rat. Single ip dosages (0, 50, and 75 mg/kg) in

Differential sensitivity to anticholinesterase insecticides in the juvenile rat: effects on thermoregulation.

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Organophosphate (OP) and carbamate (CB) insecticides inhibit cholinesterase (ChE) activity and induce acute hypothermia in adult rats. Studies showed that juveniles are generally more susceptible to neurotoxic insult than adults. However, little is known concerning the effects of OP and CB

Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome.

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Toluene, an industrial organic solvent, is voluntarily inhaled as drug of abuse. Toluene has been shown to inhibit the nicotinic acetylcholine receptors. Nicotinic receptors play an important role in brain development during brain growth spurt and early adolescence. The long-term effects of neonatal

Delayed febrile effects of chlorpyrifos: is there cross-tolerance to bacterial lipopolysaccharide?

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Oral chlorpyrifos (CHP) induces hypothermia followed by a fever that persists for several days in the rat. To understand the neuro-immune mechanisms of CHP-induced fever, we compared the tolerance and cross-tolerance between CHP and the fever elicited by lipopolysaccharide (LPS) (Escherichia coli).

Are circulating cytokines interleukin-6 and tumor necrosis factor alpha involved in chlorpyrifos-induced fever?

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Oral exposure to chlorpyrifos (CHP) in the rat results in an initial hypothermic response followed by a delayed fever. Fever from infection is mediated by the release of cytokines, including interleukin-6 (IL-6) and tumor necrosis factor (TNF alpha). This study determined if the CHP-induced fever

Effects of exercise conditioning on thermoregulatory response to anticholinesterase insecticide toxicity.

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Chronic exercise conditioning has been shown to alter basal thermoregulatory processes (change in thermoregulatory set point) as well as the response to infectious fever Chlorpyrifos (CHP), an organophosphate insecticide, also affects thermoregulation, causing an acute period of hypothermia followed

Behavioral and neurological toxicity of polybrominated biphenyls in rats and mice.

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Male, albino rats of the F-344/N strain and mice of the B6C3F1 strain were dosed by gavage, 5 days per week for a toal of 22 doses with 0.03--30 mg/kg of FireMaster FF-1, 0.168-16.8 Mg/kg of 2,4,5,2',4',5'-hexabromobiphenyl (HBB), or corn oil vehicle. A battery of tests was administered at the end

Tolerance to the hypothermic and hyperthermic effects of chlorpyrifos.

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Hypothermia is a commonly reported thermoregulatory response in rodents acutely exposed to organophosphates (OP); however, our laboratory has recently found a delayed hyperthermic response following the initial hypothermia when exposed to the OP, chlorpyrifos. It is well known that rodents display

Choice of vehicle affects pyraclostrobin toxicity in mice.

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Pyraclostrobin is a strobilurin fungicide that inhibits mitochondrial complex III of fungal and mammalian cells. In toxicity studies that were used to estimate the safety factor, pyraclostrobin was added to animal feed or to aqueous vehicles. However, foods containing residues of pyraclostrobin and

Effects of exercise conditioning on thermoregulatory responses to repeated administration of chlorpyrifos.

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Little is known about the effects of physical activity (i.e., exercise training) on susceptibility to environmental toxicants. Chlorpyrifos (CHP), an organophosphate (OP) insecticide, affects thermoregulation, causing an acute period of hypothermia followed by a delayed fever. Since exercise

A multianalyte profile of serum proteins to screen for toxicological effects of anticholinesterase insecticides in the rat.

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The development of high throughput biochemical screens could be useful to assess the broad spectrum of physiological effects of environmental toxicants. To explore the prospect of using a screen in an in vivo exposure scenario, we applied a commercially available multianalyte profile (MAP) of 58

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