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Metabolomics Explores Biomarkers for Metastatic Breast Cancer

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Imaging evaluation of the effect of chemotherapy on patients with visceral metastases from breast cancer, metabolomics was used to analyze the changes of metabolites in plasma, and to find biomarkers that could reflect visceral metastasis and treatment effects. The purpose is to help clinicians

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

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The World Health Organization (W.H.O). defines oral potentially malignant disorders (OPMDs) as "A histologically proven lesion that is associated with a significantly increased risk of malignant transformation."Oral leukoplakia is the most commonly occurring oral potentially malignant disorder.

ARAPS Study on Accelerated Liver Regeneration

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Curative intent liver resection is the gold standard for treatment of hepatic malignancies, including metastases from colorectal cancer (CRLM), but liver resection can only be performed if future liver remnant (FLR) volume is at least 25 %. Unfortunately, many cancer patients have multiple liver

Pelvic Health and Physical Therapy to Improve Lives of Prostate Cancer Patients Undergoing Prostatectomy

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This is a prospective, randomized, non-blinded, research study undergoing robotic-assisted laparoscopic prostatectomy at the University of Missouri/Ellis Fischel Hospital. Participants will be randomized in a 1:1 fashion. Data also will be tracked on those who are post-operatively stratified by

Severe Complications After Gastrectomy for Esophagogastric Junction and Gastric Cancer

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Gastrectomy is the main treatment for gastric and Siewert type II-III esophagogastric junction (EGJ) cancer. This surgery is associated with significant morbidity. The aim of the present study is to identify the predictors of postoperative morbidity and to evaluate long term survival according to

Protective Effects of the Nutritional Supplement Sulforaphane on Doxorubicin-Associated Cardiac Dysfunction

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Determine whether nutritional supplement sulforaphane (SFN) is safe to administer to breast cancer patients undergoing doxorubicin (DOX) chemotherapy. The investigators have identified biomarkers for presymptomatic detection of DOX cardiotoxicity in breast cancer patients and reported that SFN

Cancer Chemoprevention by Metformin Hydrochloride in Oral Potentially Malignant Lesions

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The idea of identifying oral lesions with a precancerous nature, that is, in the sense of pertaining to a pathologic process with an increased risk for future malignant development, of course, is to prevent frank malignancy to occur in the affected area. In 2005, WHO categorized any lesion or

Itraconazole in Non Small Cell Lung Cancer

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Lung cancer is the leading cause of cancer death in the United States The American Cancer Society estimates lung cancer incidence in the United States for 2018 to be about 234,030 and about 154,050 deaths. In 2012, GLOBOCAN estimated that 1.8 million people were diagnosed with lung cancer,

Comprehensive Care Program SBRT

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Primary objective: To evaluate the technical feasibility and delivery of a comprehensive program that leads to prevention and management of symptoms of COPD in early stage lung cancer patients undergoing curative therapy, promotes and leads to smoking cessation, and evaluates potentially unknown
Prostate cancer (PCa) is the most prevalent non cutaneous cancer in occidental countries. In Brazil incidence was about sixty thousand new cases in 2016 and occupied second place as all cancer mortality, just behind lung cancer. Literature shows than younger patients tend to have more aggressive

Prospective Versus Retrospective Complications in Radical Cystectomy and Nephrectomy

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Background: Today there are many different systems to classify co morbidity and complication of radical cystectomy and nephrectomy. Regarding complication, there is Clavien Dindo classifications System and The National Surgical Quality Improvement Program (NSQIP) while Charlson Comorbidity Index

Pembrolizumab Plus Docetaxel for the Treatment of Recurrent or Metastatic Head and Neck Cancer

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Phase III Trial of PET/CT vs. CTSurveilance for Head and Neck Cancer

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Head and neck cancer (HNC) is the sixth leading incident cancer worldwide with 600,000 cases expected in 2012.1 The vast majority of cases are head and neck squamous cell carcinoma (HNSCC), comprising > 90% of histologies. Despite advances in multimodality therapy for HNSCC, 5-year overall survival

The Clinical Relevance of Immune Cells and CTC in HNSCC Patients

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1. To establish a platform to increase the efficiency and purity for isolation and enumeration of circulating tumor cells from patients with head and neck cancer. 2. Compare the differences and determine the most efficient method or combination of negative, positive selection, optoelectronic
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