Consecutive early stage breast cancer patients who are treated according to the national guidelines. Observation over 11 years.

Breast Cancer

Breast Cancer is 100 x more frequent in female than in male

Breast Concervative or Meastectomy

Helse Stavanger HF

Helse Bergen HF

Prospective Breast Cancer Biobanking

Prospective Breast Cancer Biobanking Project

Time from surgery to relapse of breast cancer

Time from surgery until death of any cause

VAS=visual analogue scale; range 0 to 100 mm; higher score is worse fatigue)

percent of patients on disability pension i.e not participation in work

The precent of patients still on tamoxifen after 5 years and 10 years follow-up

The precent of patients still on taromatase inhibitor after 2 years and 5 years follow-up

Percent infiltration of inflammation cells (higer score means more inflammation)

Haavard Soiland

Consultant Breast Cancer Surgery / Professor dr. med.

Helse-Bergen HF

L-ornithine L-aspartate (6 ampules, each ampule containing 5 grams of the drug in 10 ml solution) to be diluted in 440 ml of Dextrose 5% (to make a total of 500 ml of solution), as intravenous infusion at the rate of 21 ml/hour, over 24 hours, for 5 days

Placebo (sterile water, 6 ampuoles of 10 ml each) diluted in 440 ml of Dextrose 5%, as intravenous infusion at the rate of 21 ml/hour, over 24 hours, for 5 days

Cirrhosis of Liver

Hepatic Encephalopathy

L-ornithine L-aspartate

Placebo (sterile water, 60 ml) diluted in 440 ml of Dextrose 5%, as intravenous infusion at the rate of 21 ml/hour, over 24 hours, for 5 days

Placebo

Department of Gastroenterology, D.M.C. and Hospital

G.B. Pant Hospital

L-ornithine L-aspartate in Overt Hepatic Encephalopathy

Efficacy of Intravenous 'L-ornithine L-aspartate' in Reversal of Overt Acute Hepatic Encephalopathy in Patients With Liver Cirrhosis: a Prospective, Randomized, Double-blind, Placebo Controlled Trial

Mental state grade according to West Haven criteria for Hepatic encephalopathy

Change in blood ammonia levels will be measured at baseline and after 5 days of treatment

Mortality rate in the two groups at 4 weeks will be compared

The total length of hospital stay (number of days) in each group will be compared.

Change in serum cytokine levels (Interleukin-1, Interleukin-6, Interleukin-10 and TNF-alpha will be measured at baseline and after 5 days of treatment.

organic acid/epuizare

Prospective Breast Cancer Biobanking

L-ornithine L-aspartate in Overt Hepatic Encephalopathy

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