Control will be 109 g white bread and 200 mL water. The glycaemic response to the test meal will be compared to the response of the control meal.

Test will be 109 g white bread and 200 mL water containing 3.819 g citric acid and 119 mg malic acid adjusted to pH 3.2. The glycaemic response to this meal will be compared to that of the control meal.

Hyperglycemia, Postprandial

Control will be 109 g white bread to be consumed together with 200 mL water

Control

Test will be 109 g white bread to be consumed together with 3.819 g citric acid and 119 mg malic acid dissolved in 200 mL water adjusted to pH 3.2.

Test

School of Food Science and Nutrition, University of Leeds

The Effects of Citric and Malic Acid Found in Pomegranate Juice on Glycaemic Response to White Bread.

The Effects of Citric and Malic Acid Found in Pomegranate Juice on Glycaemic Response

The incremental area under the glucose curve after consumption of the test meal will be compared to that obtained after the control meal

Gary Williamson

Prof functional foods

University of Leeds

L-ornithine L-aspartate (6 ampules, each ampule containing 5 grams of the drug in 10 ml solution) to be diluted in 440 ml of Dextrose 5% (to make a total of 500 ml of solution), as intravenous infusion at the rate of 21 ml/hour, over 24 hours, for 5 days

Placebo (sterile water, 6 ampuoles of 10 ml each) diluted in 440 ml of Dextrose 5%, as intravenous infusion at the rate of 21 ml/hour, over 24 hours, for 5 days

Cirrhosis of Liver

Hepatic Encephalopathy

L-ornithine L-aspartate

Placebo (sterile water, 60 ml) diluted in 440 ml of Dextrose 5%, as intravenous infusion at the rate of 21 ml/hour, over 24 hours, for 5 days

Placebo

Department of Gastroenterology, D.M.C. and Hospital

G.B. Pant Hospital

L-ornithine L-aspartate in Overt Hepatic Encephalopathy

Efficacy of Intravenous 'L-ornithine L-aspartate' in Reversal of Overt Acute Hepatic Encephalopathy in Patients With Liver Cirrhosis: a Prospective, Randomized, Double-blind, Placebo Controlled Trial

Mental state grade according to West Haven criteria for Hepatic encephalopathy

Change in blood ammonia levels will be measured at baseline and after 5 days of treatment

Mortality rate in the two groups at 4 weeks will be compared

The total length of hospital stay (number of days) in each group will be compared.

Change in serum cytokine levels (Interleukin-1, Interleukin-6, Interleukin-10 and TNF-alpha will be measured at baseline and after 5 days of treatment.

organic acid/greață

The Effects of Citric and Malic Acid Found in Pomegranate Juice on Glycaemic Response to White Bread.

L-ornithine L-aspartate in Overt Hepatic Encephalopathy

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