A pharmaceutical composition useful for aiding regression and palliation of sarcoma, lymphosarcoma and leukaemia in mammals comprises a therapeutically effective amount of a compound of formula ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen and methyl or together represent an ethylene bridging group, with the proviso that when both of the groups R.sub.1 and R.sub.2 are methyl they are disposed in the meso configuration, or a non-toxic salt thereof with a physiologically acceptable inorganic or organic acid, in combination with a physiologically acceptable diluent or carrier.

National Research Development Corporation

Pharmaceutical compositions

Antibiotic 81-484 of the following physico-chemical properties:(1) elementary analysis: C.sub.33 H.sub.48 O.sub.7 (high resolution mass spectrum);(2) molecular weight: 556 [Field desorption (FD) mass spectrum];(3) melting point: not clear (oily at 10.degree.-100.degree. C.);(4) specific rotation: [.alpha.].sub.D.sup.20 =-151.degree. (c=0.1, methanol);(5) ultraviolet absorption spectrum: shown in FIG. 1 (in methanol);(6) infrared absorption spectrum: shown in FIG. 2 (KBr tablet);(7) solubility: insoluble in hexane and water, soluble in diethyl ether, methanol, ethanol, dichloromethane, chloroform, ethyl acetate, butyl acetate, acetone and benzene;(8) nuclear magnetic resonance spectrum: shown in FIG. 3 (CDCl.sub.3, TMS);(9) nature: acidic substance;(10) color reaction:negative for ninhydrin, anthrone-H.sub.2 SO.sub.4 and ferric chloride reaction;positive for iodine and antimony trichloride;weakly positive for Zatkis reagent;or a non-toxic salt thereof, is produced by culturing Streptomyces 81-484 FERM-P 7371 in a culture medium, and isolating the thus-produced antibiotic therefrom. The antibiotic has no antibiotic activity against Gram-positive and -negative bacteria, has antimicrobial activity against some kinds of fungi, and has growth inhibitory activity against P388 mouse leukemia cells and sarcoma 180 cells.

organic acid/sarcoma

Pharmaceutical compositions

Antitumor antibiotic 81-484 and process for its production

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