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Management of chronic otitis media with effusion: the role of glutathione.

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BACKGROUND The inflammatory cells documented in chronic otitis media with effusion (OME) spontaneously release oxidants which can induce middle ear (ME) epithelial cell damage. Glutathione (GSH), a major extracellular antioxidant in humans, plays a central role in antioxidant defense. OBJECTIVE To

Effect of melatonin on lipid peroxidation, glutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs.

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Melatonin plays a role in the prevention of oxidative damage. In the present study, we investigated whether the increased oxidative stress in experimental otitis media with effusion (OME) induced by histamine is reflected in erythrocytes and middle ear effusion fluid. Lipid peroxidation in effusion

Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs.

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The aims of our study were to assess whether the increased oxidative stress in experimental otitis media with effusion (OME) induced by histamine was reflected erythrocytes and middle ear effusion fluid by lipid peroxidation; to survey the alterations in antioxidant enzyme activities in experimental

Oxidative Stress and Low Glutathione in Common Ear, Nose, and Throat Conditions: A Systematic Review.

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Context • Oxidative stress and tissue-damaging, oxygen (O2)-related, free-radical formation is inherent in human metabolism, and the tissues of the ear, nose, and throat (ENT) have an increased exposure to injury from those substances. Because glutathione (GSH) is a major component in an antioxidant

Oxidative stress in chronic otitis media with effusion.

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CONCLUSIONS The high oxidant levels in chronic otitis media with effusion (OME) observed in our research and the improvement seen in children with chronic OME after antioxidant treatment suggest that oxygen-derived free radicals play an important role in chronic OME. OBJECTIVE OME is a common

Middle ear catalase distribution in an animal model of otitis media.

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Increasing evidence implicates free radicals in the pathogenesis of inflammatory disease, including otitis media. The anti-oxidant enzymes catalase, glutathione peroxidase and superoxide dismutase protect tissues from the destructive effects of free radicals. Our previous work has shown depressed

Antioxidant role of selenium in rats with experimental acute otitis media.

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The aim of this prospective experimental animal study was to determine whether selenium had a protective effect on oxidative stress in rats with acute otitis media, by measuring the alterations of antioxidant parameters and lipid peroxidation on days 4 and 10 after inoculation into the middle ear.

Investigation of antioxidant status in children with acute otitis media and tonsillitis.

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OBJECTIVE Antioxidant enzymes status was investigated in children with acute otitis media (AOM) and acute tonsillitis. The aim was to determine the effect of oxidative damage due to free radicals on the antioxidant enzymes status in children with AOM and acute tonsillitis. METHODS We measured

The Anti-Inflammatory and Antioxidant Effects of Curcumin in Middle Ear Infection.

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OBJECTIVE To investigate and analyze the anti-inflammatory and antioxidant efficacy of curcumin in experimentally induced middle ear infection. METHODS Twenty-four Wistar albino rats with otomicroscopic examination findings within normal limits were included in the study. Study groups were

Recurrence of antigen-induced otitis media by thiol compound.

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Reduced glutathione (GSH), a potential factor in the chronicity of human otitis media, was tested to determine its potency in the recurrence of antigen-induced otitis media in chinchillas sensitized with human serum albumin (HSA). GSH instillation into the healing middle ear bulla reproduced a level

The evaluation of oxidative stress in the serum and tissue specimens of patients with chronic otitis media.

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OBJECTIVE To underline the effect of oxidative stress in chronic otitis media with and without cholesteatoma and to compare the oxidative stress values in the serum and tissue specimens in these two forms. METHODS The study included a total of 75 individuals, 35 cases with chronic otitis media (COM;

Efficacy of vitamin A in experimentally induced acute otitis media.

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OBJECTIVE Vitamin A plays a role in the prevention of oxidative tissue damage. In the present study we investigated therapeutic role of this substance on healing of middle ear mucosa in experimental acute otitis media (AOM). METHODS Otitis media was induced by inoculating Streptococcus pneumoniae

The role of oxidants and antioxidants in otitis media with effusion in children.

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OBJECTIVE Determine the possible role of oxidants and antioxidants in the pathogenesis of otitis media with effusion in children. METHODS Randomized controlled trial, tertiary referral center. The study group was made up of children with otitis media with effusion who were to undergo bilateral

Oxidant and antioxidant levels in children with acute otitis media and tonsillitis: a comparative study.

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OBJECTIVE Recurrent episodes of acute otitis media (AOM) and acute tonsillitis (AT) are a common problem in infectious disorders during childhood and are major cause of morbidity in children. The organism maintains defense systems including nonenzymatic antioxidants such as Vitamins A, E and C and

The role of free oxygen radicals on the development of otitis media with effusion.

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OBJECTIVE The purpose of this study was to determine if free oxygen radicals (FORs) and antioxidant enzyme activities have some role in pathogenesis of otitis media with effusion (OME) in children with adenoid hyperplasia. METHODS Seventy-four patients were enrolled in three groups of this study.

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