4 rezultate
Background Endocrine resistance is a significant problem in the management of breast cancer, with increasing evidence that the tumour microenvironment is influential on tumour growth and disease resistance. The neoadjuvant setting provides an excellent opportunity to observe tumour response to
Main objectives of the project:
- To evaluate the usefulness of radiofrequency ablation (RFA) to achieve a lower percentage of positive margins.
- To validate clinically the efficacy and safety of the method in breast tumors smaller than < 2 cm.
Specific objectives of the project:
1. To demonstrate
Cancer is accompanied by increased oxidative stress and induction of polymorphic cytochrome P- 450 mixed oxidase enzymes (CYP). Both processes affect the abundance of volatile organic compounds (VOCs) in the breath because oxidative stress causes lipid peroxidation of polyunsaturated fatty acids in
OBJECTIVES:
Primary
- Compare progression-free survival of postmenopausal women with, estrogen receptor- and/or progesterone receptor-positive recurrent or advanced breast cancer treated with exemestane with versus without SOD1 inhibitor ATN-224.
- Establish the safety of SOD1 inhibitor ATN-224 in