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Substituted 1,4,-di-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists

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CROSS REFERENCE TO RELATED APPLICATIONS This application is the national stage of Application No. PCT/EP2003/50697, filed Oct. 7, 2003, which application claims priority from PCT Patent Application No. PCT/EP02/11328 filed Oct. 8, 2002. and priority from PCT Patent Application No. PCT/EP02/14836

Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists

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FIELD OF THE INVENTION This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NK.sub.1 antagonistic activity, a combined NK.sub.1/NK.sub.2 antagonistic activity, a combined NK.sub.1/NK.sub.3 antagonistic activity and a combined

Diaza-spiro-{4,4}-nonane derivatives as neurokinin (NK.sub.1) antagonists

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FIELD OF THE INVENTION This invention concerns substituted diaza-spiro-[4.4]-nonane derivatives having neurokinin antagonistic activity, in particular NK.sub.1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or

Substituted diaza-spiro-[5.5]-undecane derivatives and their use as neurokinin antagonists

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CROSS REFERENCE TO RELATED APPLICATIONS This application is the national stage of Application No. PCT/EP2005/051508, filed 4 Apr. 2005. which application claims priority from PCT/EP2004/050457 filed 6 Apr. 2004. FIELD OF THE INVENTION This invention concerns substituted diaza-spiro-[5.5]-undecane

Substituted oxa-diaza-spiro-[5.5]-undecanone derivatives and their use as neurokinin antagonists

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CROSS-REFERENCE TO RELATED APPLICATIONS This application is the National Stage of International Application No. PCT/EP2006/060419, filed Mar. 3, 2006, which claims the benefit of EP Application No. 05101657.4, filed Mar. 3, 2005, the disclosures of which are incorporated herein by reference in their

Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders

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FIELD OF THE INVENTION The present invention relates to novel conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds possess appropriate pharmacological

Benzodiazepine derivatives

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This invention relates to new benzodiazepine derivatives and pharmaceutically acceptable salts thereof. More particularly, it relates to new benzodiazepine derivatives and pharmaceutically acceptable salts thereof which are cholecystokinin (CCK) antagonists and therefore can be used as therapeutical

Benzodiazepine derivatives

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Benzimidazolone derivatives

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TECHNICAL FIELD This invention relates to substituted benzimidazolone derivatives which are useful in the field of pharmaceuticals. More specifically, the invention relates to substituted benzimidazolone derivatives exhibiting selective antagonist activities against muscarinic acetylcholine receptor

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