physostigmine/seizures

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Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries.

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The antidotal, anticonvulsant and neuroprotective effects of physostigmine (PhS) and procyclidine (PC), the combinational prophylactics for organophosphate poisoning, were evaluated. For the investigation of dose-response relationship in rats and guinea pigs, various doses (0-6 mg/kg) of PC in

Scopolamine-induced convulsions in food given fasted mice: effects of physostigmine and MK-801.

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We recently reported that scopolamine pretreated mice fasted for 48 h developed clonic convulsions soon after they were allowed to eat a small amount of food for 30 s. The present experiments were performed to determine whether animals also develop convulsions when they were allowed to eat ad

Changes in physostigmine-induced hippocampal seizures during ethanol withdrawal.

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Hippocampal cholinergic neurons are sensitive to acute ethanol administration, and specific alterations are seen in the functioning of these neurons following chronic ethanol. The present study examined the effects of chronic ethanol exposure and withdrawal on the sensitivity of the hippocampus to

Effect of scopolamine on physostigmine potentiated convulsions produced by pentylenetetrazole in rats.

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Convulsions after physostigmine.

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Lithium involvement in physostigmine-induced seizures.

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Effects of tetrahydroaminoacridine (tacrine) derivatives and physostigmine in convulsions induced by pentylenetetrazol.

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Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?

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Current treatment of organophosphate poisoning is insufficient, and survivors may suffer from long-lasting adverse effects, such as cognitive deficits and sleep-wake disturbances. In the present study, we aimed at developing a guinea pig model to investigate the benefits of immediate and delayed

A Comparison of Resource Utilization in the Management of Anticholinergic Delirium Between Physostigmine and Nonantidote Therapy.

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Background: Antimuscarinic delirium is associated with significant morbidity, and its management requires substantial resource allocation, including intubation, restraint, and intensive care unit (ICU) placement. There is controversy over the management of these patients. Physostigmine can

Synergism of the toxicity of physostigmine and neostigmine by lithium or by a reserpine-like agent (Ro4-1284).

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A single sublethal i.p. dose of lithium chloride (300 mg/kg or 7.1 meq/kg) followed 12 h later by an otherwise sublethal s.c. dose of physostigmine sulfate (1.0 mg/kg) resulted in 90% mortality among male rats following a pronounced cholinergic syndrome, including convulsions. This confirms a

Cholinergic effects on arousal and cocaine-induced olfactory-amygdala spindling and seizures in cats.

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Effects of intravenous cholinergic and dopaminergic agents on pre-cocaine olfactory bulb (OB) spindling and behavioral arousal, and on cocaine-induced OB-amygdala spindling and behavioral seizures were evaluated in seven cats with stereotaxically implanted electrodes. Spindle data were computer

Susceptibility of Flinders sensitive and resistant rats to pharmacologically induced seizures.

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The Flinders sensitive (FSL) and Flinders resistant (FRL) line rats have been selectively bred for hyper- and hyposensitivity to the hypothermic effect of cholinergic agonists respectively. In this study, pilocarpine (250 mg/kg) and physostigmine (0.8 mg/kg) doses that are subconvulsant to outbread

Pharmacological validation of a semi-automated in vitro hippocampal brain slice assay for assessment of seizure liability.

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BACKGROUND Drug-induced seizures are a serious, life-threatening adverse drug reaction (ADR) that can result in the failure of drugs to be licensed for clinical use or withdrawn from the market. Seizure liability of potential drugs is traditionally assessed using animal models run during the later

A guinea pig hippocampal slice model of organophosphate-induced seizure activity.

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Extracellular recording techniques have been used in the guinea pig hippocampal slice preparation to investigate the electrophysiological actions of the organophosphate (OP) anticholinesterase soman. When applied at a concentration of 100 nM, soman induced epileptiform activity in the CA1 region in

Cromakalim, a Potassium Channel Opener, Ameliorates the Organophosphate and Carbamate-Induced Seizure in Mice.

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Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies. In the present experiment, the possible effect of

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