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prostaglandin/diaree
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Preventing enteropooling induced diarrhea by prostacyclin or 11-oxo-prostaglandin administration
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BACKGROUND OF THE INVENTION
Numerous agents, such as diarrheogenic prostaglandins, various parasitic oranisms, and toxins produced by microbial agents, are known in the art to have a recognized diarrheogenic potential in mammals. One measure of the potential for the induction of diarrhea for a given
2-Substituted prostaglandins
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BACKGROUND OF THE INVENTION
U.S. Pat. Nos. 3,965,143; 4,087,621; 4,060,691 and 4,322,543 extensively disclose 16 alkyl, 16 hydroxy prostaglandins. Compounds of the present invention structurally differ from the prior art compounds by substitution at the 2 position. For example, the prior art
Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use
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BACKGROUND OF THE INVENTION
This invention relates to prostaglandin antagonists useful in treating a variety of conditions, such as allergic asthma where excessive contractile activity of prostaglandins and prostaglandin biosynthetic intermediates occur.
These compounds antagonize the actions of
Tetrahydrocarbazole 1-alkanoic acids and pharmaecutical compositions
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BACKGROUND OF THE INVENTION
This invention relates to prostaglandin antagonists useful in treating a variety of conditions, such as allergic asthma where excessive contractile activity of prostaglandins and prostaglandin biosynthetic intermediates occur.
These compounds antagonize the actions of
Indole-2-alkanoic acids compositions of and anti allergic use thereof
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SUMMARY OF THE INVENTION
This invention relates to prostaglandin antagonists useful in treating a variety of conditions, such as allergic asthma where excessive contractile activity of prostaglandins and prostaglandin biosynthetic intermediates occur.
These compounds antagonize the actions of
Tetrahydrocarbazole esters, pharmaceutical compositions and use
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BACKGROUND OF THE INVENTION
This invention relates to prostaglandin antagonists useful in treating a variety of conditions, such as allergic asthma where excessive contractile activity of prostaglandins and prostaglandin biosynthetic intermediates occur.
These compounds antagonize the actions of
Cyclohept(B)indolealkanoic acids, pharmaceutical compositions and use
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DESCRIPTION OF THE INVENTION
The present invention relates to novel compounds of Formula I: ##STR1## wherein: A is --(CR.sup.9 R.sup.10).sub.r R.sup.11 ;
R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently selected from:
(1) hydrogen;
(2) alkyl having 1 to 6 carbon
Cyclohept[b]indoleakanoic acids, pharmaceutical compositions and use
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BACKGROUND OF THE INVENTION
This invention relates to prostaglandin antagonists useful in treating a variety of conditions, such as allergic asthma where excessive contractile activity of prostaglandins and prostaglandin biosynthetic intermediates occur.
These compounds antagonize the actions of
Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
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Log In / Înregistrare
BACKGROUND OF THE INVENTION
This invention relates to prostaglandin antagonists useful in treating a variety of conditions, such as allergic asthma where excessive contractile activity of prostaglandins and prostaglandin biosynthetic intermediates occur.
These compounds antagonize the actions of
Cyclohept[b]indolealkanoic acids, pharmaceutical compositions and use
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DESCRIPTION OF THE INVENTION
The present invention relates to novel compounds of Formula I: ##STR1## wherein:
A is --(CR.sup.9 R.sup.10).sub.r R.sup.11 ; R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently selected from:
(1) hydrogen;
(2) alkyl having 1 to 6 carbon
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