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prostaglandin/febră
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Pagină 1 din 32 rezultate
Prostaglandin receptor EP1
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The present invention relates to a novel polypeptide prostaglandin E (hereinafter, simply referred to as "PGE") receptor.
In more detail, the present invention relates to (1) a novel polypeptide, (2) a cDNA encoding the polypeptide and a fragment selectively hybridized to the sequence of the cDNA,
Use of a benzoyl derivative of 3-aminocarbazole for the treatment of a disorder associated with the production of prostaglandin E.sub.2 (PGE.sub.2)
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FIELD OF THE INVENTION
This invention relates to the use of a benzoyl derivative of 3-aminocarbazole in Table 1 below for the production of a pharmaceutical which is useful in the treatment of disorders associated with the production of prostaglandin E.sub.2 (PGE.sub.2) such as, for example,
N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly 3-hydroxybenzothiophenes having the unusual 2-enamido side chains, such as those of Formula I: ##STR2##
Compounds of formula I have been found to be effective inhibitors of both cyclooxygenase and lipoxygenase and
3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor
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FIELD OF THE INVENTION
The present invention relates to novel 3-aminocarbazole compounds, to a pharmaceutical composition containing them, to a method for preparing them, and to the use of such compounds for the production of a drug that is useful in the treatment of disturbances associated with the
3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor
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CROSS REFERENCES TO RELATED APPLICATIONS
This application is a 371 of International Patent Application No. PCT/EP2009/055652, filed on May 11, 2009, and claims priority to European Patent Application No. 08425336.8, filed on May 14, 2008.
FIELD OF THE INVENTION
The present invention relates to novel
3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor
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FIELD OF THE INVENTION
The present invention relates to novel 3-aminocarbazole compounds, to a pharmaceutical composition containing them, to a method for preparing them, and to the use of such compounds for the production of a drug that is useful in the treatment of disturbances associated with the
Multibinding inhibitors of cyclooxygenase-2
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel multibinding compounds (agents) that inhibit the enzyme cyclooxygenase-2 (COX-2) and to pharmaceutical compositions comprising such compounds. Accordingly, the multibinding compounds and pharmaceutical compositions
Antibodies to MCP-4
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This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are human
Human chemokines, CK.beta.4 and CK.beta.10/MCP-4
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This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are human
Human chemokine beta-10 mutant polypeptides
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FIELD OF THE INVENTION
The present invention relates to deletion and substitution mutant polypeptides of human chemokine beta-10 (Ck.beta.-10), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the
Human chemokine beta-10 mutant polypeptides
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FIELD OF THE INVENTION
The present invention relates to deletion and substitution mutant polypeptides of human chemokine beta-10 (Ck.beta.-10), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the
5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to benzothiophenes, particularly, 3-hydroxybenzo[b]thiophene-2-carboxamides, which are found to be effective cyclooxygenase and 5-lipoxygenase inhibitors and are therefore useful in the treatment of inflammation and other prostaglandin and
Human chemokine .beta.-9 viral vectors
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FIELD OF THE INVENTION
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present
Antibodies to chemokine .beta.-4
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FIELD OF THE INVENTION
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly,
Human Ck.beta.-10 polynucleotides
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FIELD OF THE INVENTION
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly,
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