prostaglandin/neoplasms

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Method of treating neoplastic cells with prostaglandin and radiation treatment or prostaglandin and platinum-based anti-tumor agents

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates generally to a method of treating neoplastic cells with prostaglandin. More particularly, a therapeutically effective amount of ionizing radiation required to treat a neoplasm in a subject can be reduced by administering

Prostaglandin-F2 alpha receptor modulators and uses thereof

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FIELD OF THE INVENTION The present invention generally relates to prostaglandin-F2 alpha (PGF2.alpha.) receptor modulation and uses thereof for the treatment of conditions associated with PGF2.alpha. receptor activity such as preterm labor and colorectal cancer. BACKGROUND OF THE INVENTION Preterm

Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto

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BACKGROUND Status epilepticus is a condition in which the brain is in a state of persistent seizure. There is evidence that 30-60 minutes of persistent seizure is sufficient to damage neurons and that such a seizure is unlikely to self-terminate. Status epilepticus survivors may die soon after or

Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto

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BACKGROUND Status epilepticus is a condition in which the brain is in a state of persistent seizure. There is evidence that 30-60 minutes of persistent seizure is sufficient to damage neurons and such a seizure is unlikely to self-terminate. Status epilepticus survivors may die soon after or have

Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto

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BACKGROUND Status epilepticus is a condition in which the brain is in a state of persistent seizure. There is evidence that 30-60 minutes of persistent seizure is sufficient to damage neurons and such a seizure is unlikely to self-terminate. Status epilepticus survivors may die soon after or have

Pyrimidine compounds inhibiting the formation of nitric oxide and prostaglandin E2, method of production thereof and use thereof

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FIELD OF ART The invention concerns polysubstituted pyrimidine derivatives showing the effect of a simultaneous decrease in the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and their use as medicaments. BACKGROUND ART The specialized literature provides reliable data that long-term

Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH

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FIELD OF INVENTION This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or

Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH

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Methods for using a phosphodiesterase in pharmaceutical screening to identify compounds for treatment of neoplasia

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BACKGROUND OF THE INVENTION This invention provides a method for identifying compounds potentially useful for the treatment and prevention of pre-cancerous and cancerous lesions in mammals. This application is a continuation of U.S. patent application Ser. No. 08/866,027 to Piazza et al. Filed May

Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds

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BACKGROUND OF THE INVENTION This application claims priority under 35 U.S.C. .sctn.120 to U.S. Patent App. Ser. Nos. 08/866,027 and 09/046,739, filed May 30, 1997 and Mar. 24, 1998, respectively. This invention relates to the use of one or more forms of phosphodiesterase type 2 ("PDE2") and

Composition and method for cancer chemoprevention

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BACKGROUND 1. Field Methods and compositions for cancer chemoprevention. In particular, methods and compositions that inhibit growth and/or development of tumors. 2. Background Prostaglandins are members of a group of lipid compounds derived enzymatically from fatty acids and are found in nearly all

Use of diterpene compound as a therapeutic agent of inflammation, immune disease or cancer

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FIELD OF THE INVENTION The present invention relates to a novel use of diterpene compounds as a therapeutic agent for the treatment of inflammatory disease, immunological disease or cancer. BACKGROUND OF THE INVENTION Exposure of human tissue or cells to harmful stimuli such as lipopolysaccharide

Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer

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TECHNICAL FIELD This invention relates to a prostaglandin E2 receptor 4 (EP4) antagonist for use in the treatment of nonalcoholic steatohepatitis (NASH)-associated liver cancer. The method for treatment of NASH-associated liver cancer comprises administering any one of Compound A, Compound B or

Selective EP4 receptor antagonistic substance for treatment of cancer

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This application is a U.S. national stage of International Application No. PCT/JP2010/057114 filed Apr. 22, 2010. TECHNICAL FIELD This invention relates to use of a compound which has inhibitory activities against prostaglandin E2 receptor (EP4 receptor) and is represented by the following general

Selective EP4 receptor antagonistic substance for treatment of cancer

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TECHNICAL FIELD This invention relates to use of a compound which has inhibitory activities against prostaglandin E2 receptor (EP4 receptor) and is represented by the following general formula (I), (II), (III), or (IV), or a pharmaceutically acceptable salt thereof (hereafter it is sometimes called

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