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Mechanisms by which resistant starches and non-starch polysaccharide sources affect the metabolism and disposition of the food carcinogen, 2-amino-3-methylimidazo[4,5-f]quinoline.

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Although both non-starch polysaccharides (NSP) and resistant starches (RS) are included in current definitions of dietary fibre, our previous work has suggested fundamental differences in the way in which these two classes of material affect the disposition and absorption of a dietary carcinogen.

Adsorption of direct-acting and indirect-acting mutagens by various dietary fibers.

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The protective effect of dietary fiber on human cancer has received great attention during the last decades. Because dietary fiber constitutes a large group of complex polysaccharides with various solubilities, degrees of lignification, chemical compositions and structural arrangements, several

Endophytic fungi from Miquelia dentata Bedd., produce the anti-cancer alkaloid, camptothecine.

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Camptothecine (Campothecin, CPT), a quinoline alkaloid, is a potent inhibitor of eukaryotic topoisomerase I. Several semi-synthetic derivatives of CPT are in clinical use against ovarian, small lung and refractory ovarian cancers. While CPT is produced by several plant species belonging to the

Suberized plant cell walls suppress formation of heterocyclic amine-induced aberrant crypts in a rat model.

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Dietary fibre is believed to protect against a range of Western diseases, including colorectal cancer. Whole plant cell walls make up most of the dietary fibre in Western diets, but their role in disease protection has rarely been studied. At least in vitro, suberized plant cell walls possess novel

A new furoquinoline alkaloid with antifungal activity from the leaves of Ruta chalepensis L.

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Bioassay-guided separation with an eye toward antifungal activity led to the isolation of the new alkaloid 5-(1̀,1̀-dimethylallyl)-8-hydroxyfuro[2-3-b] quinoline (1) and the known biscoumarin daphnoretin (2) as the active constituents of the chloroform extract obtained from the leaves of Ruta

Structure of ferric pseudobactin, a siderophore from a plant growth promoting Pseudomonas.

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Both plant growth promoting Pseudomonas B10 and its yellow-green, fluorescent iron transfer agent (siderophore) pseudobactin enhance the growth of the potato and control certain phytopathogenic microorganisms. The structure of the little compound has been determined by single-crystal X-ray

Detection and partial characterization of a human mast cell carboxypeptidase.

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Using a high performance liquid chromatography assay that detects the cleavage of the C-terminal leucine from angiotensin I, we have identified a carboxypeptidase activity in mast cells from human lung and in dispersed mast cell preparations from human skin. The enzyme activity was detected in a

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