Ivermectin has been reported to be a SARS-CoV-2 inhibitor. This activity is believed to be due to the dependence of many different RNA viruses on IMPα / β1 during infection. These reports suggested that the inhibitory activity of ivermectin nuclear transport may be effective against SARS-CoV-2, since they demonstrate that ivermectin has antiviral action against the clinical isolate of SARS-CoV-2 in vitro, with a single dose capable to control viral replication in 24-48 hours. in vitro

Severe Acute Respiratory Syndrome

Ventilation Pneumonitis

Ivermectin 5 MG/ML

Hospital Eurnekian

IVERMECTIN Aspirin Dexametasone and Enoxaparin as Treatment of Covid 19

EVALUATION of Ivermectin Aspirin Dexametasone and Enoxaparin as Treatment of covid19

Considering healing and/or reducing symptoms and severity of initial presentation

Keeping the patient(s) out of ICU, as they do not need mechanical ventilation and/or special intensive care

potential need of reducing or augmenting doses

Outcome of adverse effects to one or more drugs used in the clinical trial

Personal data will remain secret. Only clinical descriptions (age, gender, co-morbidities, evolution, outcomes will be released

Hector E Carvallo

Principal investigator

Eurnekian Public Hospital

Patients with significant carotid stenosis without intracranial stenosis.

Patients with carotid and intracranial stenosis.

Patients with lone intracranial stenosis.

Patients with no significant carotid or intracranial stenosis.

Ischemic Stroke

Carotid Stenosis

Carotid duplex+/- MRA neck

brain MRA and or CT angiography on carotid and brain

brain MRA+/-CT angio on carotid and brain

MRI brain with diffusion to detect asymptomatic stroke

MRI brain

DSA (digital subtraction angiography) in some cases to confirm diagnosis.

DSA (digital subtraction angiography)

Mansoura University Hospital

Extracranial Carotid & Intracranial Arterial Stenosis in Ischemic Stroke

Association Between Extracranial Carotid & Intracranial Arterial Stenosis in Ischemic Stroke Patients: Predictors & Outcome

The National Institutes of Health Stroke Scale is a tool used by healthcare providers to objectively quantify the impairment caused by a stroke. The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0. The higher score indicate poor outcome.

The modified Rankin Scale is a commonly used scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. It has become the most widely used clinical outcome measure for stroke clinical trials. The higher score indicate poor outcome.

The Beck Depression Inventory, created by Aaron T. Beck, is a 21-question multiple-choice self-report inventory, one of the most widely used psychometric tests for measuring the severity of depression.

Ahmed Esmael

Assistant Prof of Neurology

Atherothrombosis

Aspirin

Triflusal

Atherothrombosis Research Centre / Laboratory of Biochemistry, University of Ioannina

ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)

Comparison of Triflusal With Aspirin in the Secondary Prevention of Atherothrombotic Events

Number of participants who suffer from the primary efficacy end point which is the composite of death from vascular causes, myocardial infarction(MI), or stroke during the twelve month treatment period

Number of participants who suffer from the rate of bleeding events as defined by Bleeding Academic Research Consortium (BARC) criteria during the twelve month treatment period

Number of participants who suffer from the secondary efficacy end point which is the composite of death from any cause, MI, or stroke during the twelve month treatment period

Number of participants who suffer from the secondary safety end points which are hypersensitivity or intolerance to study drugs during the twelve month treatment period

Alexandros Tselepis

Professor of Biochemistry and Clinical Chemistry

University of Ioannina

Warfarin therapy is continued without interruption prior to cardiac pacing device implantation

Warfarin therapy is discontinued 2 days prior to cardiac pacing device implantation

Patients with aspirin therapy during implantation

No antithrombotic treatment during operations

Hemorrhage

Thrombosis

Embolism

Warfarin is either interrupted or uninterrupted prior to device implantation

Warfarin

Aspirin is continued without interruption prior to device implantation

Devices are implanted tailored each patient's clinical condition and need following local practices, national and international guidelines.

Permanent pacemaker

Implantable Cardioverter-defibrillator

Turku University Hospital

Anticoagulant Therapy During Pacemaker Implantation

Randomized Trial of Uninterrupted Versus Interrupted Anticoagulant Therapy in Patients Undergoing Cardiac Pacing Device Implantation

Juhani Airaksinen

Professor

University of Turku

Satakunta Central Hospital

Oulu University Hospital

Tampere University Hospital

Arterial Occlusive Diseases

Clopidogrel

Sanofi-Aventis

CASPAR : Clopidogrel and Acetyl Salicylic Acid in Bypass Surgery for Peripheral ARterial Disease

A Double-blind, Randomized Study of Clopidogrel 75 mg/d vs Placebo, on a Background of ASA 75-100 mg/d,in Peripheral Arterial Disease (PAD) Patients Receiving a Unilateral Below Knee Bypass Graft.

salicylic acid/accident vascular cerebral

IVERMECTIN Aspirin Dexametasone and Enoxaparin as Treatment of Covid 19

Extracranial Carotid & Intracranial Arterial Stenosis in Ischemic Stroke

ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)

Anticoagulant Therapy During Pacemaker Implantation

CASPAR : Clopidogrel and Acetyl Salicylic Acid in Bypass Surgery for Peripheral ARterial Disease

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