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Lysine acetyl salicylic acid in acute renal pain.

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The effect of repeated doses of 1.8 g lysine acetyl salicylic acid (LAS) i.v. on severe pain secondary to acute renal colic (ARC) was studied in 45 consecutive patients. Clinically acceptable analgesia was obtained in 65% of the cases. No additional pain relief was achieved with the combination of

Painless dental extraction in children.

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A controlled investigation was undertaken to compare topical lignocaine and rectal paracetamol in the prevention of pain after day case dental extraction in children under general anaesthesia. Sixty patients were allocated randomly to receive intraoperatively either topical lignocaine 4 mg/kg (group

[High dose fosfestrol in phase I-II trial for the treatment of hormone-resistant prostatic adenocarcinoma].

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Androgen deprivation displays the mean therapy of advanced stage prostatic cancer, independently of palliative radiotherapy. The evolution to hormone-resistance status leads to a fatal tumor progression. High-dose fosfestrol (diethylstilbestrol diphosphate) has been suggested to circumvent

Testicular torsion: a diagnosis not to be missed.

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A 25-year-old male was seen in the outpatient with complaints of left testicular swelling and intermittent pain for 4 years, aggravated 8 months back in association with nausea and vomiting. There was no history of trauma, or fever and no lower urinary tract symptoms (LUTS) were present. After

[Dose-dependent side effects of acetylsalicylic acid therapy. Results of a prospective randomized clinical study in patients with peripheral arterial occlusive disease].

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METHODS In 359 patients with peripheral arterial occlusive disease who had undergone percutaneous transluminal angioplasty (PTA), a randomized double-blind, controlled clinical study was done to investigate the tolerability of acetyl salicylic acid (ASA) given for reocclusion prophylaxis. A

Antiaggregatory, physiological and clinical effects of ticlopidine in subjects with peripheral atherosclerosis.

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Twelve patients with varying degrees of peripheral atherosclerotic disease were given an antiaggregatory drug, ticlopidine [5-(6-chlorobenzyl)-4,5,6,7-tetrahydrothieno-(3,2-C)-pyridine HCl] in a single blind trial for one or four months and the effects on platelet aggregation, blood coagulation,

Mild analgesics as an alternative to ergotamine in migraine. A comparative trial with acetylsalicylic acid, ergotamine tartrate, and a dextropropoxyphene compound.

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The effect of ergotamine tartrate was compared with that of acetylsalicylic acid and a dextropropoxyphene compound (Doleron novum) on 525 acute migraine attacks in a double-blind crossover study of 25 adult female patients. Ergotamine tartrate and the dextropropoxyphene compound were equally

[Double blind study of intravenous aspirin vs placebo in the treatment of acute migraine attacks.].

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BACKGROUND The empirical use of oral acetylsalicylic acid (ASA) in the treatment of acute migraine attacks has led to the recommendation of ASA as a basic treatment of migraine. However, there are no controlled studies on the intravenous use of acetylsalicylic acid. METHODS Forty patients with a 1-

Topical tretinoin: a new treatment for black hairy tongue (lingua villosa nigra).

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Black hairy tongue is the name given to the appearance of an abnormal coating of the tongue and occurs only in adults. It is the result of hyperkeratosis of the filiform lingual papillae which, on gross examination appear hair-like with a variable tinctorial aspect from yellow-brown to black. The

Salicylate intoxication in the elderly. Recognition and recommendations on how to prevent it.

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Aspirin (acetylsalicylic acid) and its salicylate derivatives are effective antipyretic, analgesic, and anti-inflammatory agents that are still very widely used by the elderly despite the advent of newer, potentially safer nonsteroidal anti-inflammatory drugs (NSAIDs). However, none of the new

Pharmacokinetics of nicotine carbomer enemas: a new treatment modality for ulcerative colitis.

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BACKGROUND Ulcerative colitis is largely a disease of nonsmokers, and transdermal nicotine is of therapeutic value in the active disease. Because side effects are common, we developed a topical enema formulation of nicotine. OBJECTIVE To study the pharmacokinetics of nicotine complexed with a

Treatment of cobalamin C (cblC) deficiency during pregnancy.

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OBJECTIVE To report the successful pregnancy of a woman with methylmalonic acidemia and hyperhomocysteinemia, cblC type [cobalamin C (cblC) deficiency] (MIM 277400). METHODS Retrospective chart review. RESULTS A 24-year-old woman presented at 14 weeks gestation with nausea, self-restricted protein

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