sterol/seizures

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Lovastatin exacerbates atypical absence seizures with only minimal effects on brain sterols.

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AY-9944 (AY) exacerbates chronic recurrent seizures in rats that are analogous to atypical absence epilepsy in humans. The mechanism by which AY affects the slow spike-and-wave discharges associated with these seizures is not known, but is thought to involve inhibition of cholesterol synthesis. We

Brain sterols in the AY-9944 rat model of atypical absence seizures.

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OBJECTIVE The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined. METHODS Long-Evans

A novel frameshift mutation in the sterol 27-hydroxylase gene in an Egyptian family with cerebrotendinous xanthomatosis without cataract.

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Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid storage disorder caused by deficiency of the mitochondrial cytochrome P450 sterol 27-hydroxylase enzyme encoded by CYP27A1 gene. CTX is characterized by tendon xanthomas, juvenile cataracts and multiple progressive neurological

Increased deposition of cholesterol in brain after electroconvulsive seizure.

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Rats injected intracranially with cholesterol precursors and subjected to electroconvulsive seizures showed significantly higher levels of deposition of [4-14C]cholesterol into brain cholesterol than controls. The degree of incorporation was cholesterol greater than mevalonic acid greater than

Pathogenic mutations of the human mitochondrial citrate carrier SLC25A1 lead to impaired citrate export required for lipid, dolichol, ubiquinone and sterol synthesis.

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Missense mutations of the human mitochondrial citrate carrier, encoded by the SLC25A1 gene, lead to an autosomal recessive neurometabolic disorder characterised by neonatal-onset encephalopathy with severe muscular weakness, intractable seizures, respiratory distress, and lack of psychomotor

Bioactive non-sterol triterpenoid from Streblus asper: microwave-assisted extraction, HPTLC profiling, computational studies and neuro-pharmacological evaluation in BALB/c mice.

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BACKGROUND In folk medicine, the stem bark of Streblus asper Lour. (Moraceae) has been reported to possess anticonvulsant activity. However, no systematic/scientific validation is available. Objective This study explores the constituents in the stem bark, their biosassy-guided isolation and their

Chemical profiling of heroin recovered from the North Korean merchant vessel Pong Su.

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Heroin samples, seized from the North Korean merchant vessel Pong Su in Australian waters, were analyzed to determine geographic origin. Duplicate samples were analyzed by the National Measurement Institute's Australian Forensic Drug Laboratory and the United States Drug Enforcement Administration's

Evaluation of the Anticonvulsant Activity of the Leaves of Glycyrrhiza glabra var. glandulifera Grown in Iran, as a Possible Renewable Source for Anticonvulsant Compounds.

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A review of the publications in traditional medicine indicates that the root of Glycyrrhiza glabra L., Fabaceae, is recommended for treatment of epilepsy. As a renewable source, the leaves of G. glabra var. glandulifera growing in Iran were examined for possible anticonvulsant activity. The

Pathophysiology of cerebrotendinous xanthomatosis.

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Cerebrotendinous xanthomatosis (CTX) is a rare autosomal-recessive lipid storage disease caused by mutations in the CYP27A1 gene, which lead to deficiency of the mitochondrial enzyme, sterol 27-hydroxylase, resulting in the accumulation of cholestanol in the serum and many affected lesions. To date,

Induction of chronic epileptiform activity in the rat by an inhibitor of cholesterol synthesis, U18666A.

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Earlier work in our and other laboratories suggest that alteration of brain lipids, primarily sterols, could be a precondition for the development of epileptiform activity. The present study further tests this hypothesis by attempting to produce chronic epileptiform activity in the rat by a drug

[Progress of researches on acupuncture treatment of diseases by regulating endoplasmic reticulum stress].

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Endoplasmic reticulum stress (ERS) is one of the major defense networks in mammals, but continuous ERS will lead to cell apoptosis, inducing initiation and progression of many human diseases. Biochemical, physiological and pathological stimuli induced ERS may help the cells adapt to and survive

Evaluation of the sedative properties of the ethanolic root extract of Cissampelos mucronata.

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The ethanolic root extract of Cissampelos mucronata was investigated for sedative activity. Phytochemical analysis indicated the presence of alkaloids: sterols/triterpenes, tannins, carbohydrates, glycosides, and flavonoids. Acute lethality test gave an LD50 of 282.84 mg/kg. The study of the effect

Ficus hispida Linn.: A review of its pharmacognostic and ethnomedicinal properties.

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Ficus hispida (FH) Linn. is a moderate sized tree found throughout the year and is grown wild or cultivated for its edible fruits and folklore value. Traditionally, different parts of the plant have been used in the treatment of ulcers, psoriasis, anemia, piles jaundice, vitiligo, hemorrhage,

Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice.

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Brain cholesterol homeostasis has been shown to be disrupted in neurodegenerative conditions such as Alzheimer's and Huntington's diseases. Investigations in animal models of seizure-induced brain injury suggest that brain cholesterol levels are altered by prolonged seizures (status epilepticus) and

Anticonvulsant Activity of Hydroalcoholic Extract and Aqueous Fraction of Ebenus stellata in Mice.

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OBJECTIVE Fabaceae is the third largest family of flowering plants. Lack of essential oils in the plants of this family can be considered as an advantage and can favor them in search for safe and antiepileptic medicines. The effects of Fabacea family plants including Ebenus stellata (E. stellata),

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