A novel treatment for topical inflammatory conditions such as acne, eczema, shingles, insect bites and hives is provided, consisting of the application of a pharmaceutical cream or ointment which incorporates hydroxypropyl methylcellulose acetate succinate ("HPMCAS") in a micronized form and which preferably contains one or more thickeners, a bio-adhesive agent and water so that the formulation, when applied, can stick to the area to be treated.

Composition for the treatment of inflammatory conditions

Compounds of general formula (I) in which Y and Q are the same or different and are hydrogen atoms or C.sub.1-6 alkyl groups, optionally substituted by 1-4 hydroxy or 1-4 R.sup.3 O.sub.2 CCH.sub.2 CH.sub.2 CO.sub.2 -- groups, where R.sup.3 is a hydrogen atom or a C.sub.1-6 alkyl group which may be straight or branched and saturated or unsaturated, and R.sup.1 and R.sup.2 are the same or different and are C.sub.1-6 alkyl groups, which may be straight or branched and saturated or unsaturated, and solvates and prodrugs of these compounds and the salts of compounds in which R.sup.3 is a hydrogen atom. These compounds can be used in the treatment of diseases caused by or resulting in metabolic dysfunction and/or energy deprivation, such as diabetes, acute starvation, endotoxemia, sepsis, systemic inflammatory response syndrome and multiple orgen dysfunction syndrome. ##STR1##

Leo Pharmaceuticals Products Ltd. A/S

Polyol succinates and their pharmaceutical formulation

This invention describes a comprehensive nutraceutical designed to antagonize major mitigating factors to the degenerative process associated with Parkinson's disease. The formulation is comprised of a primary base of pyruvate, succinate, .alpha.-Ketoglutarate and/or oxaloacetate, niacin/NADH, fruit extracts, anthocyanins, further combined with specific macro/micronutrients, trace elements, amino acids, flavonoids and concentrated plant sources. The nutraceutical contains all natural substances that should mitigate many of the neurodegenerative processes known to be associated with PD. Mechanisms addressed are to prevent the loss of ATP/by 1-methyl-4-phenylpyridinium rotenone, scavenge hydrogen peroxide/O.sub.2..sup.-, augment antioxidant enzymes, prevent dopamine (DA) oxidation to DA-quinone via inhibition of COX, PLA.sub.2, LOX, xanthine oxidase, tyrosinase, prevent hyperhomocysteinemia, antagonize PARP-1 apoptosis, increase blood flow, glucose and oxygen delivery to the brain, potentiate mitochondrial function, antagonize glia iNOS and MAO or its products, chelate redox-active iron, inhibit heme oxygenase-1, inhibit alpha-synuclein aggregation, augment ATP storage, mediate anti-inflammatory effects via inhibition of PDE, MAPK p38/c-Jun NH2-terminal kinase/PGE2, antagonize excitotoxicity and downregulate N-methyltransferase, all of which contribute toward PD pathology.

Mazzio; Elizabeth Anne

Soliman; Karam F

Florida A &amp; M University

Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease

A pharmaceutical composition comprising at least one local anesthetic, at least one anti-inflammatory agent and at least one antibiotic are disclosed. The local anesthetic has a peak effect no later than about 10 minutes after administration to a mammal, and the anesthetic and anti-inflammatory have a half-life of no greater than about 36 hours after administration. The pharmaceutical composition, thus, advantageously provides rapid relief of pain with a substantially low residual accumulation of active components so that the pharmaceutical composition can be repeatedly or continuously administered to a wound. Embodiments include preparing a medicinal solution including Lidocaine as the local anesthetic, Hydrocortisone sodium succinate as the anti-inflammatory agent, Chloramphenicol as the antibiotic agent and, optionally, Heparin as an anticoagulant. The medicinal solution is continuously administered to treat a wound of a mammal to maintain a constant positive physiological pressure in the treated wound at a pressure to enable permeation of the medicinal solution and fluids from the wound with concomitant periodical suctioning of debris from the wound.

succinate/inflamație

Composition for the treatment of inflammatory conditions

Polyol succinates and their pharmaceutical formulation

Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease

Fast-acting pharmaceutical compositions and methods of use

Cea mai completă bază de date cu plante medicinale susținută de știință