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Vitamin E and breast cancer.

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Vitamin E is a term that describes a group of compounds with similar yet unique chemical structures and biological activities. One interesting property possessed by certain vitamin E compounds-namely, delta-tocotrienol, RRR-alpha-tocopheryl succinate [vitamin E succinate (VES), a hydrolyzable

α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis.

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Metastasis formation requires active energy production and is regulated at multiple levels by mitochondrial metabolism. The hyperactive metabolism of cancer cells supports their extreme adaptability and plasticity and facilitates resistance to common anticancer therapies. In spite the potential

Urinary metabolite and lipid alterations in Colombian Hispanic women with breast cancer: A pilot study.

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Metabolic biomarkers for breast cancer (BC) prognosis and diagnosis are required, given the increment of BC incidence rates in developing countries and its prevalence in women worldwide. Human urine represents a useful resource of metabolites for biomarker discovery, because it could reflect

Vitamin E succinate promotes breast cancer tumor dormancy.

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BACKGROUND Vitamin E succinate (VES) is the most potent antitumor analogue of vitamin E. Despite many reports of VES's antitumor activity in vitro, there is little information about its antitumor effects in vivo. METHODS We investigated the effect of VES on the growth of human breast cancer cells in

LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer.

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Cisplatin is one of the most common anticancer agents for treating different kinds of solid tumors today. However, its broader therapeutic applications are limited by the severe side effects and nonspecific biodistribution. In this study, luteinizing hormone-releasing hormone (LHRH)-targeted

Radiolabeled L-lysine for tumor imaging.

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OBJECTIVE The aims of this study were to label the versatile amino acid l-lysine with (99m)Tc using 2,3-dimercapto-succinic acid (DMSA) as a chelator, and to assess its tumor imaging feasibility under in vivo and in vitro conditions, and finally to determine the subcellular biodistribution of this

Doxorubicin loaded 17β-estradiol based SWNT dispersions for target specific killing of cancer cells.

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The present work reports the synthesis of a 17β-estradiol based amphiphiles comprising of polyethylene glycol (PEG) moiety linked through succinic acid that non-covalently dispersed (76%) the single walled carbon nanotubes (SWNTs) in water. The superior exfoliation of carbon nanotubes was

Synthesis and biological evaluation of paclitaxel and vorinostat co-prodrugs for overcoming drug resistance in cancer therapy in vitro.

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Paclitaxel (PTX) is the first-line treatment drug for breast cancer. However, drug resistance after a course of treatment and low selectivity restricted its clinical utility sometimes. In this study, we successfully bound PTX and vorinostat (SAHA) to form co-prodrugs based on the synergistic

Dendritic molecular capsules for hydrophobic compounds.

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Reichardt's dye, a highly solvatochromic dye, was encapsulated within poly (glycerol succinic acid) ([Gn]-PGLSA-OH) dendrimers to investigate the interior environment of these dendritic macromolecules. The absorption maximum for the encapsulated Reichardt's dye in water was indicative of a

α-Tocopherol succinate improves encapsulation and anticancer activity of doxorubicin loaded in solid lipid nanoparticles.

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This work aimed to develop solid lipid nanoparticles (SLN) co-loaded with doxorubicin and α-tocopheryl succinate (TS), a succinic acid ester of α-tocopherol that exhibits anticancer actions, evaluating the influence of TS on drug encapsulation efficiency. The SLN were characterized for size, zeta

pH and redox dual-sensitive polysaccharide nanoparticles for the efficient delivery of doxorubicin.

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A pH and redox dual-sensitive biodegradable polysaccharide, succinic acid-decorated dextran-g-phenylalanine ethyl ester-g-cysteine ethyl ester (Dex-SA-l-Phe-l-Cys), was synthesized to load doxorubicin hydrochloride (DOX·HCl). The DOX-loaded nanoparticles, which were prepared in aqueous solution and

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence

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Background: The tuber of Pinellia ternata has been used for a thousand years in China. P. ternata possessed the activities of anti-emetic, sedative-hypnotic, anti-cancer, anti-asthmatic, anti-tussive, and anti-inflammatory. It is the

Simultaneous Diels-Alder click reaction and starch hydrogel microsphere production via spray drying

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Herein, starch was used as a raw material to produce hydrogel microspheres via a strategy that combines spray drying and a Diels-Alder reaction. First, the starch was modified with N-maleoyl alanine and succinic acid amide. Second, starch hydrogel microspheres (SGPs) and drug-loaded hydrogel

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