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Synthetic apelin fatty acid conjugates with improved half-life

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FIELD OF THE INVENTION The present invention relates to compositions comprising semi synthetic biologic molecules which are bioconjugates of an APJ agonist polypeptide and a fatty acid moiety. In particular, the bioconjugates of the invention, while retaining APJ agonistic activity, exhibit greater

Synthetic apelin mimetics for the treatment of heart failure

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 28, 2013, is named PAT054961-US-NP_SL.txt and is 67,220 bytes in size. FIELD OF THE

Synthetic apelin mimetics for the treatment of heart failure

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Log In / Înregistrare
SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 28, 2013, is named PAT054961-US-NP_SL.txt and is 67,220 bytes in size. FIELD OF THE

Synthetic apelin mimetics for the treatment of heart failure

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Log In / Înregistrare
SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 28, 2013, is named PAT054961-US-NP_SL.txt and is 67,220 bytes in size. FIELD OF THE

Disulfide cyclic polypeptides for the treatment of heart failure

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FIELD OF THE INVENTION The invention relates to novel compositions comprising modified peptide and polypeptide sequences designed to treat cardiovascular disease in subjects to whom they are administered, and which exhibit greater resistance to degradation, and equivalent or greater bioactivity than

Synthetic linear apelin mimetics for the treatment of heart failure

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FIELD OF THE INVENTION The invention relates to novel compositions comprising modified peptide and polypeptide sequences designed to treat cardiovascular disease in subjects to whom they are administered, and which exhibit greater resistance to degradation, and equivalent or greater bioactivity than

Cyclic polypeptides for the treatment of heart failure

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FIELD OF THE INVENTION The invention relates to novel compositions comprising modified peptide and polypeptide sequences designed to treat cardiovascular disease in subjects to whom they are administered, and which exhibit greater resistance to degradation, and equivalent or greater bioactivity than

Cyclic polypeptides for the treatment of heart failure

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Sep. 29, 2014, is named PAT055418-US-NP_SL.txt and is 44,387 bytes in size. FIELD OF THE

Cyclic apelin derivatives for the treatment of heart failure

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Sep. 29, 2014, is named PAT055656_SL.txt and is 14,498 bytes in size. FIELD OF THE

Bioconjugates of synthetic apelin polypeptides

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Sep. 26, 2014, is named PAT055781-US-NP.sub.13 SL.txt and is 118,077 bytes in size. FIELD
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