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Serum 17-OH progesterone and free testosterone levels in women patients with Familial Mediterranean Fever: a pivotal study.

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BACKGROUND Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by short lived, febrile serosae inflammatory attacks. FMF has various effects in multiple systems and organs. OBJECTIVE In the present study, our aim was to evaluate adrenal steroidogenesis in female FMF

Nocturnal hyperthermia induced by social stress in male tree shrews: relation to low testosterone and effects of age.

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Stress is known to elevate core body temperature (CBT). We recorded CBT in a diurnal animal, the male tree shrew, during a one-week control period and a one-week period of social stress using a telemetric system. During the stress period, when animals were confronted with a dominant male for about

Signaling pathways for germ cell death in adult cynomolgus monkeys (Macaca fascicularis) induced by mild testicular hyperthermia and exogenous testosterone treatment.

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Male contraception has focused, to a great extent, on approaches that induce azoospermia or severe oligospermia through accelerated germ cell apoptosis. Understanding the specific steps in the germ cell apoptotic pathways that are affected by male contraceptives will allow more specific targeting in

Testicular hyperthermia reduces testosterone concentrations and alters gene expression in testes of Nelore bulls.

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Increased testicular temperature reduces sperm motility, morphology and fertility. Our objectives were to characterize effects of testicular hyperthermia (scrotal insulation) on acute testosterone concentrations and gene expression in Bos indicus testes. Nelore bulls (n = 20), ∼27 mo of age, 375 kg,

Effects of testosterone on fever and vasopressin mRNA in wether sheep given endotoxin.

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This study investigated the effects of testosterone on the febrile response of castrated rams to immunological challenge. Core temperature was recorded by radiotelemetry in wethers (n = 6) injected with lipopolysaccharide endotoxin or saline before and after androgen treatment. The number of cells

transient scrotal hyperthermia and levonorgestrel enhance testosterone-induced spermatogenesis suppression in men through increased germ cell apoptosis.

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BACKGROUND In rodents and monkeys, a combination of hormonal and physical agents accelerates germ cell death. OBJECTIVE A "proof of concept" study was performed to investigate whether addition of heat exposure or a progestin to an androgen induces germ cell death and more complete and rapid

Testosterone production by a Leydig tumor cell line is suppressed by hyperthermia-induced endoplasmic reticulum stress in mice.

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OBJECTIVE Leydig cells are characterized by their ability to produce testosterone. When the Leydig cells are unable to produce enough testosterone, spermatogenesis fails completely. Considering this, it is of great interest to investigate whether the expressions of steroidogenic enzymes are affected

Effects of scrotal hyperthermia on Leydig cells in long-term: a histological, immunohistochemical and ultrastructural study in rats.

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We have previously demonstrated that scrotal hyperthermia induce Leydig cell (LC) damage in short-term. The objectives of this pilot study were to investigate morphological changes and regulation of steroidogenesis on LC in long-term and the time of observation were extended to investigate whether

Morphodynamic and biochemical assessment of seminal plasma in patients who underwent local prostatic hyperthermia.

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Fourteen young and sexually active patients with chronic abacterial prostatitis who failed to respond to conventional medical therapy underwent four 60 minute sessions of local prostatic hyperthermia. Calculated prostatic temperature was 42 +/- 0.5 degrees C. Analysis of seminal plasma was performed

Effects of flunixin meglumine on selected clinicopathologic variables, and serum testosterone concentration in stallions after endotoxin administration.

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Four clinically normal stallions were infused intravenously with endotoxin (LPS) from Escherichia coli 055:B5 at a dose of 0.3 microg/kg b.w. and four stallions were treated with flunixin meglumine (FM) as a single intravenous injection at a dose of 1.1 mg/kg b.w., 5 min after the infusion of LPS.

Sex-related differences in fever development of rats.

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Lipopolysaccharide (LPS) or partially purified endogenous pyrogen (EP) was injected intravenously into rats of both sexes to induce fever. In LPS fever, which was easily produced in 24-h dehydrated rats with an intravenous injection of LPS, the female rats showed an attenuated febrile reaction as

Acute evaluation of pituitary function in patients with Crimean-Congo haemorrhagic fever.

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BACKGROUND Crimean-Congo haemorrhagic fever (CCHF) can cause a fatal haemorrhagic syndrome. Pituitary ischaemia/infarction and necrosis are known causes of hypopituitarism, often remaining unrecognized because of subtle clinical manifestations. OBJECTIVE Our aim was to evaluate the effect of CCHF on

Studies on endocrine changes induced by 8 MHz local radiofrequency hyperthermia in patients with bladder cancer.

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To elucidate changes in hormone metabolism, especially thyroid, cortisol and sex hormone metabolism, during acute local heat stress, serum-free thyroxine (FT4), free tri-iodothyronine (FT3), reverse T3 (rT3), thyroxine binding globulin (TBG) and a number of other hormone levels [thyroid-stimulating

Testicular function in patients with familial Mediterranean fever on long-term colchicine treatment.

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Sperm counts and hormonal studies were carried out in six patients with familial Mediterranean fever who were receiving long-term colchicine therapy. The duration of therapy ranged between 7 and 31 months. In all subjects, spermograms, testosterone, follicle-stimulating hormone, luteinizing hormone,

[Acne fulminans following high-dose testosterone treatment in tall boys].

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In three boys, aged 12.5, 14 and 16 years, respectively, acne of the fulminans type developed after eight to twelve months' administration of 250 mg testosterone weekly or 500 mg every second week. Numerous deep and painful pustules grew, dominantly on the chest and back, in one of the boys also in

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