theophylline/febră

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Effects of theophylline on anesthetized malignant hyperthermia-susceptible pigs.

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BACKGROUND Theophylline was shown to induce contracture development in porcine malignant hyperthermia (MH) susceptible (MHS) skeletal muscles in vitro. The purpose of the current study was to investigate the in vivo effects of theophylline in MHS and MH normal (MHN) swine. METHODS MH-trigger-free

Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats.

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This investigation was designed to determine the effect of fever on the neurotoxicity of theophylline as reflected by the concentrations of this drug that cause convulsions in experimental animals. Fever was produced in male, inbred, adult Lewis rats (approximately 180 g) by sc injection of brewer's

Influence of endotoxin-induced fever on the pharmacokinetics of theophylline in the rabbit model.

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To assess fever-induced changes in theophylline pharmacokinetics in the rabbit model, six healthy, male, New Zealand white rabbits were studied using a randomized, matched-pair design. In treatment 1, 15 mg/kg of theophylline was infused into the left marginal ear vein, and several blood samples

[A case of theophylline-associated seizures with postictal fever and postictal pleocytosis].

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We report a 70-year-old man who developed theophylline-associated seizure with postictal fever and postictal pleocytosis. He was admitted to our hospital for a left hemiconvulsion lasting for two hours. The concentration of theophylline was high (21.6ng/ml), and electroencephalogram demonstrated

Influences of pyrexia and age on theophylline clearance in young children with asthma.

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Fifty hospitalized children with asthmatic bronchitis and bronchial asthma were treated with a continuous intravenous drip infusion of aminophylline. To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a

Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever.

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1. The effects of malaria infection due to Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of orally-administered caffeine (CA: 10 mg/kg) to its primary metabolites (theobromine (TB), paraxanthine (PX) and theophylline (TH)) were studied in 5-week-old male Wistar

Fever-induced changes in theophylline pharmacokinetics in rats.

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Our aim was to document possible alterations of theophylline pharmacokinetics in rats during fever. Two groups (group A = normothermic controls, group B = fever-induced animals) of Wistar AF IOPS male rats were injected at 19 30 h either with 2 g/kg of brewer's yeast subcutaneously (20% w/v) or with

[Theophylline induces contractures in porcine skeletal muscle preparations with the disposition to malignant hyperthermia].

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OBJECTIVE Theophylline, a methylxanthine, leads to an increase of the cytoplasmic Ca(2+)-concentration in the muscle cell. Since the in-vitro contracture test (IVCT) with halothane and caffeine does not distinguish a 100% between malignant hyperthermia susceptible (MHS) and non-susceptible (MHN), we

Is theophylline, aminophylline, or caffeine (methylxanthines) contraindicated in malignant hyperthermia susceptible patients?

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Grand mal seizure induced by oral theophylline.

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A grand mal convulsion occurred in a patient with decompensated cor pulmonale. Although only modest doses of oral theophylline were being administered at the time of the convulsion the serum theophylline level was markedly raised and the theophylline clearance was very low. After treatment for cor

Salbutamol versus theophylline for wheezy infant.

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OBJECTIVE To compare the tolerability and efficacy of salbutamol and theophylline in treating wheezy infant. METHODS This was a prospective parallel group study. METHODS Wheezy infants admitted in paediatric ward of Khulna Medical College Hospital from January 1998 to March

Are current pediatric dose recommendations for intravenous theophylline appropriate?

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Theophylline, a first-line antiasthma drug, is often associated with severe toxicity even when taken in the recommended schedule. Theophylline toxicity has been associated with upper respiratory tract infections (URTI) due to reduced total-body clearance of theophylline. Some researchers believe

Problems with generic theophylline and indiscriminate brand switching.

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Theophylline is a very efficacious medication for the treatment of bronchospastic disorders: however, it has a narrow therapeutic range of 10 to 20 micrograms/mL. Pharmacokinetics of theophylline can be affected by diverse factors, such as viral infections, fever, circadian rhythms, food ingestion,

Field trial of theophylline in cattle with respiratory tract disease.

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A field trial was conducted to determine the efficacy of theophylline in relieving respiratory distress associated with bovine respiratory disease complex (shipping fever). Theophylline (as aminophylline capsules) was administered PO at a dosage of 28 mg/kg of body weight daily for 3 days to 20

[Evaluation of theophylline in children hospitalized with asthma attack].

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The purpose of this study is to determine whether theophylline provides clinical benefits in the hospitalized children with asthma attack. Aminophylline was intravenously given to the 50 patients (Group A) who were admitted 1994. A small dose of aminophylline compared to that of Group A was given to

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