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tuberculosis/phosphatase
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Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis
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FIELD OF THE INVENTION
Aspects of this disclosure relate to the synthesis and use of salicylic acid derivatives to selectively inhibit various tyrosine phosphatases.
BACKGROUND AND SUMMARY
According to the World Health Organization, about one third of the world's population is infected with
Polypeptide nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis
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The subject of the invention is novel recombinant screening, cloning and/or expression vectors which replicate in mycobacteria. Its subject is also a set of sequences encoding exported polypeptides which are detected by fusions with alkaline phosphatase and whose expression is regulated (induced or
Desaturase antigen of mycobacterium tuberculosis
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BACKGROUND OF THE INVENTION
Tuberculosis and leprosy, caused by the bacilli from the Mycobacterium tuberculosis complex and M. leprae respectively are the two major mycobacterial diseases. Pathogenic mycobacteria have the ability to survive within host phagocytic cells. From the interactions between
Desaturase antigen of mycobacterium tuberculosis
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BACKGROUND OF THE INVENTION
Tuberculosis and leprosy, caused by the bacilli from the Mycobacterium tuberculosis complex and M. leprae respectively are the two major mycobacterial diseases. Pathogenic mycobacteria have the ability to survive within host phagocytic cells. From the interactions between
Mutants of mycobacteria and process thereof
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FIELD OF THE INVENTION
The present invention provides an attenuated mutant Mycobacterium strain wherein the mutant strain is incapable of expressing the active tyrosine phosphatase and is impaired in its ability to survive in activated macrophages and animals. The invention also provides a method
Mycobacterium mutants for vaccines with improved protective efficacy
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TECHNICAL FIELD
The present invention relates to the field of vaccines, most particularly, live attenuated Mycobacterium-based vaccines. Disclosed herein are genes that, when mutated in mycobacteria used for immunization of animals, particularly mammals, confer improved protective efficacy as a
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