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Isoleucine Intake and Intermediary Metabolism in Type 2 Diabetes

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Defects in mitochondrial β-oxidation and branched chain amino acid (BCAA) oxidation are associated with type 2 diabetes (T2D) and other conditions such as Huntington's disease and maple syrup urine disease. Because of these defective mitochondrial pathways, production of TCA cycle intermediates can

SOAR-2: Intervening in Obesity Through Reduction of Dietary Branched Chain Amino Acids

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Effect of the Quality of Dietary Proteins on the Sleep Young Elite Athletes and the Obese Adolescent

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Double-blind controlled pre-post trial where each subject acts as his own control. Three measurement sessions will be performed for each teenager. Each session will be conducted over a week. Each teenager will participate in three protein enrichment sessions: PROT1 session, PROT2 session, and

Investigation of an Amino Acid Supplement on Glucose Levels in Obese Subjects

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1. BCAA's multiple functions in cells In addition to participating in de novo protein synthesis, Branched-Chain Amino Acids (BCAAs, including leucine, isoleucine, and valine) regulate multiple cellular functions as nutrient signaling. For example, BCAAs regulate insulin and glucagon secretion and

Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity

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Atherosclerosis is the underlying cause of cardiovascular diseases (CVD), the major cause of death worldwide. Atherosclerosis is an inflammatory disease of the arteries in which activated macrophages are abundant in the atherosclerotic lesions. Macrophages play key roles during early atherogenesis.

Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects

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Branched-Chain Amino Acids (BCAAs, including leucine, isoleucine, and valine) regulate multiple cellular functions as nutrient signaling. For example, BCAAs regulate insulin and glucagon secretion and thus glucose metabolism1. BCAAs, especially leucine, is one key regulator of mTOR signaling, which

The Effect of Branched-Chain Amino Acid Supplementation and Exercise on Body Composition During Energy Restriction

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This double blind placebo study will take place over an 8 week treatment period of diet and exercise. All participants (n=16) will be placed on the same hypocaloric diet and exercise program. Both groups will exercise at the same time. Baseline habitual 3 day food logs, waist to hip ratio and BodPod

Nutritive Efficacy and Safety of a Modified Infant Formula With a Reduced Protein Content and Improved Protein Quality

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Breast milk is considered the gold standard for early childhood nutrition, it is optimized in terms of ingredients to the needs of the infant in the first months of life. Formula differ in many ways in their composition to breast milk, e.g. in the structure and concentration of the protein

Comparison of Different Weight Loss Diets With Different Protein Content

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The prevalence of obesity globally and in Singapore continues to rise despite increased public awareness and efforts to control weight. Its association with chronic metabolic diseases, including diabetes, hypertension, cardiovascular diseases, signify the serious implications of obesity on public

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