valproic acid/seizures

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Pharmacokinetic parameters of total and unbound valproic acid and their relationships to seizure control in epileptic children.

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The aims of this study were to define the relationship between total and unbound valproic acid (VPA) concentrations, to compare pharmacokinetic parameters of total and unbound VPA, and to determine the difference in pharmacokinetic parameters between the seizure-controlled and -uncontrolled groups.

Intermittent prophylaxis in febrile convulsions: diazepam or valproic acid?

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In an open, prospective, randomized, and hospital-based study, comprising 219 consecutive children, 169 were given intermittent prophylaxis for one year, receiving either diazepam or valproic acid after their first febrile convulsion. Children admitted on odd dates (n = 89) were given rectal

Prophylactic treatment with valproic acid or diazepam in children with febrile convulsions.

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The purpose of this study was to limit prophylactic treatment of children with febrile convulsions to patients who have the highest risk of recurrence. Two hundred and thirty-one children with a first febrile seizure were divided into high- and low-risk groups according to estimated risk of

Levocarnitine induced seizures in patients on valproic acid: A negative systematic review.

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OBJECTIVE Warnings of L-carnitine induced seizures are recorded on product monographs and pharmacy databases, without any referenced literature. This medication can potentially improve the hospital course in those patients with valproic acid (VPA) induced hyperammonemic encephalopathy, but may be

Absence seizures aggravated by valproic acid.

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OBJECTIVE To report on pediatric patients with absence epilepsy who experienced absence seizure aggravation while receiving valproic acid (VPA). METHODS The charts of all children from four pediatric epilepsy clinics receiving VPA for absence epilepsy were reviewed. Patients were evaluated and

Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway.

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OBJECTIVE The current study evaluates the anticonvulsant effect of valproic acid (VPA) alone or combined with low dose γ-irradiation (LDR) against pentylenetetrazol-induced convulsions in rats. METHODS Five groups of rats were used, group I served as normal control, group II served as PTZ- control

Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.

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Propylisopropyl acetamide (PID) and valnoctamide (VCD) are two CNS-active constitutional isomers of valproic acid (VPA) corresponding amide (and prodrug) valpromide. VPA is a major antiepileptic drug (AED) used also in children. Consequently, the purpose of the current study was to see if PID, VCD

Correlation between alterations in brain GABA metabolism and seizure excitability following administration of GABA aminotransferase inhibitors and valproic acid-a re-evaluation.

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The time course of the effects of aminooxyacetic acid, ?-vinyl GABA, ?-acetylenic GABA, gabaculine, ethanolamine-O-sulphate (EOS) and valproic acid (VPA) on brain GABA content and the activities of glutamic acid decarboxylase (GAD) and GABA aminotransferase (GABA-T), the enzymes involved in

Single-dose model for predicting steady-state valproic acid serum concentrations in seizure patients.

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Valproic acid serum concentrations predicted by a single-dose prediction model were compared with steady-state serum concentrations measured after the start of therapy in seizure patients. Ten patients receiving valproic acid for the first time or who had not been taking the drug for two or more

Effect of valproic acid on spike and wave discharges in patients with absence seizures.

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Twenty-five patients with absence seizures were treated with valproic acid in doses from 17 to 62.5 mg per kilogram per day. Nineteen patients experienced reduction of spike and wave discharges; in 11 it was greater than 75 percent. Twenty-one patients had a reduction of the total time of spike and

Lamotrigine and absence seizures: new indication. Try valproic acid first.

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In a trial including 38 children, lamotrigine, which had to be introduced very gradually in order to reduce the risk of potentially severe skin reactions, took longer than valproic acid to control typical absence seizures.

Valproic acid and intractable seizures in severely brain-damaged patients.

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We treated 52 mentally retarded patients with intractable seizures by adding valproic acid (VPA) to other drug regimens. Sixty-one percent improved clinically. VPA significantly reduced the frequency of generalized tonic-clonic seizures, generalized myoclonus, absence and atonic seizures. There was

Acute seizures due to a probable interaction between valproic acid and meropenem.

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OBJECTIVE To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures. METHODS A 21-year-old woman presented to our emergency department because of a new-onset, generalized tonic-clonic seizure and was admitted to the intensive care

Valproic acid therapy inducing absence status evolving into generalized seizures.

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The authors herein present two children with mild absence epilepsy, having intermittent absences, who developed absence status evolving into atonic generalized seizures and drop attacks along with progressive disorientation induced by relatively small doses of valproic acid. Consciousness and

Valproic Acid Suppositories for Management of Seizures for Geriatric Patients.

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This case describes the use of valproic acid suppositories for secondary seizure prophylaxis in a geriatric veteran with a feeding and swallowing disorder. The effectiveness of valproic acid suppositories is outlined to reinforce the need for compounding pharmacies to have this formulation available

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