xanthine/neoplasms

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Short-term Clinical Study of CN128 in Thalassemia Patients

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1. Primary objectives: - To study the tolerance and safety of multiple oral administration of CN128 in patients with thalassemia aged 16 years and above. - To study the pharmacokinetics of CN128 in thalassemia patients aged 16 and above by multiple oral administrations of CN128 2. Design: The study

Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.

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Hyperuricemia is considered one of the risk factors for arterial hypertension in postmenopausal women. The recent analysis by Loeffler confirmed that, as indicated in the NHANES survey, uric acid is a powerful cardiovascular risk factor.Analysis of age and sex strata in a meta-analysis showed

Urate Lowering Therapies and Left Ventricular Diastolic Dysfunction

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Between 1, July 2018 and 31, Dec 2018, consecutive individuals with metabolic syndrome hyperuricemia are candidates of the present study. After the eligible candidates sign the informed consent, they will receive blood tests with a fasting time of 8 hours at least. The investigators will randomize

Clinical Study of CN128 in Thalassemia Patients

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1. Primary objectives: · To determine the maximum tolerated dose (MTD) of CN128 for single oral administration in thalassemia patients aged 16 and above · To study the pharmacokinetics of CN128 in thalassemia patients aged 16 and above 2. Design: The study is designed as a randomized, double-blind,

Methylprednisolone N Acetylcysteine in Hepatic Resections

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Elective liver resection is performed mainly for benign and malignant liver tumors. The malignant tumors may arise primarily within the liver (hepatocellular carcinoma and cholangiocarcinoma) or represent metastases from malignancies of other organs. During hepatic resection, the risk of severe

Mucomyst for Hepatitis C

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The Effects of N-Acetylcysteine on Oxidative Stress in Chronic Hepatitis C Objective: There is evidence that suggests oxidative stress plays a role in the pathologic mechanism of disease progression in chronic hepatitis C virus infection (HCV). This study will test the hypothesis that

Pegylated Recombinant Mammalian Uricase (PEG-uricase) as Treatment for Refractory Gout

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Inflammatory arthritis in patients with gout is caused by crystals of monosodium urate (MSU) that form as a result of chronically elevated levels of uric acid in plasma and extracellular fluids. Recurrent attacks can usually be prevented by treatment with drugs that block urate synthesis by

Treatment of Pulmonary Sarcoidosis With Pentoxifylline

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Corticosteroids are currently the mainstay of therapy for active pulmonary sarcoidosis and are used to prevent relapses in many patients with stable disease. The pulmonary manifestations of sarcoidosis are heterogenous and not all patients require corticosteroid therapy. Corticosteroids often

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