Endocrine Research 1985
Biopharmaceutic stability of [D-Trp6, des-Gly10]-LHRH ethyl amide in corn oil.
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When sperm-positive female rats were treated with freshly prepared formulations of [D-Trp6, des-Gly10]-LHRH ethyl amide (LRA) in corn oil, the effects on pregnancy occurred in a dose-related manner. When the same formulation was retested after five-and-a-half years of storage under refrigeration, the results were essentially identical. Therefore, the biopharmaceutic stability of corn oil formulations of LRA appears to be 100% following five-and-a-half years of storage at 4 degrees C.
