[Cyclicity, reversibility and compensation of magnetobiological reactions in isolated cells and tissues].

Cell sensitivity to a constant magnetic field (CMF) of 100 = 200 Oe was studied on a fibroblast culture using time-lapse microfilming. It was expressed in the phasic development of the motility of cells, intracellular structures and inclusions: a short-term latent phase (10-15 min), an excitation phase (1.5-2 h) and a suppression phase (up to the end of exposure). After field removal the return of cells to the initial state with a slight excess (in 1.5-2 h) was noted. The phasic development, reversibility and compensation of magnetobiological reactions were later on confirmed in studies on the inhibition in CMF of 400-600 Oe of the activity of succinate dehydrogenase and peptidase in isolated surviving rat skeletal muscles, liver and kidney as well as on a model of the reaction of a cytopathogenic effect of lymphocytes from patients with rheumatic fever on human embryonic fibroblasts where a noticeable effect of inhibition with the CMF action on the system of lymphocytes-fibroblasts and, on the contrary, of its activation with adding to fibroblasts lymphocytes preexposed in CMF of 400-600 Oe for 1 and 24 h were revealed and interpreted as supercompensation of the inhibited enzymatic activity of immunocompetent cells. The phasic development, reversibility and compensation of magnetobiological reactions should be necessarily taken into account in working out magnetotherapy.