[Effect of hypokinesia and lowered barometric pressure on the tolerance of animals to the action of ethyl acetate].

Experiments were carried out to study the resistance of rats to an acute effect of ethylacetate vapors at concentrations of 25 to 69 g/m-3 after their 20-day exposure to hypokinesia and 20-day exposure to altitudes of 3200 and 5000 m. The effect of ethylacetate at concentrations of 47 and 10 mg/m-3 on the rats in a chronic 90-day experiments was also investigated. After an exposure to hypokinesia and hypoxia the sensitivity of the rats to an acute effect of ethylacetate vapors increased 2- or 3-fold. The chronic inhalation of the substance by the hypokinetic animals brought about disorders in the brain microstructure and renal pathology. The poisoned animals that retained normal motor activity displayed serious pathological changes in the thyroid gland. It is concluded that changes in the reactivity of the animal and human body to chemical agents must be taken into consideration when developing standards for the space cabin atmosphere.