The antinociceptive and anti-inflammatory effects of a long-acting depot formulated ketorolac in rats.
Ключевые слова
абстрактный
BACKGROUND
Currently, no long-acting nonsteroidal anti-inflammatory drug is available clinically for the treatment of long-lasting pain. The aim of the study was to evaluate the antinociceptive and anti-inflammatory effects and duration of action of a novel depot formulation of ketorolac benzyl ester in sesame oil.
METHODS
Two studies in Sprague-Dawley rats were carried out. In study 1, the antinociceptive and anti-inflammatory effects of intramuscular ketorolac tromethamine were evaluated. In study 2, the antinociceptive and anti-inflammatory effects of intramuscular ketorolac benzyl ester were evaluated. The antinociceptive effect was evaluated using the paw pressure test, whereas the anti-inflammatory effect was evaluated by the paw edema test.
RESULTS
Intramuscular ketorolac tromethamine at 24, 80, and 240 micromol/kg (in saline) produced significant antinociceptive and anti-inflammatory effects with duration of action around 6 to 8 h. Ketorolac benzyl ester at a dose of 240 micromol/kg (in oil) produced significant long-acting antinociceptive and anti-inflammatory effects with duration of action of 56 h.
CONCLUSIONS
Intramuscular injection of ketorolac benzyl ester (in sesame oil) in rats produced antinociceptive and anti-inflammatory effects which were 7-fold longer in duration of action than ketorolac tromethamine (in saline).
