The fixation effect of a silk fibroin-bacterial cellulose composite plate in segmental defects of the zygomatic arch: an experimental study.
Ключевые слова
абстрактный
OBJECTIVE
Bioresorbable fixation systems have been popular for the treatment of facial fractures. However, their mechanical properties are uncertain and complications have been reported. To overcome these problems, we developed a bioresorbable fixation plate using a composite of silk fibroin and bacterial cellulose (SF-BC) with biodegradability and increased biocompatibility.
OBJECTIVE
To investigate the regenerative effect of the bioresorbable SF-BC fixation plate on zygomatic arch defects in rats.
METHODS
In vivo animal study. The SF-BC composite plate had a tensile strength similar to that of a polylactic acid plate and a tight, pore-free microstructure. Bilateral segmental bone defects (2 mm in length) were created in the zygomatic arches of adult rats. One side was fixed with the SF-BC composite plate, and the other side was left without fixation.
METHODS
Academic research laboratory.
METHODS
Fifteen adult Sprague-Dawley rats.
METHODS
Fixation of the zygomatic arch defect with the SF-BC composite plate.
METHODS
Micro-computed tomography and histological evaluation of bone samples.
RESULTS
Gross inspection revealed no specific complication. At 1, 2, 4, and 8 postoperative weeks, the zygomatic arches were explored by micro-computed tomography and histological examination. Control sides did not heal completely and showed bony degeneration and necrosis during the 8-week follow-up. However, we observed new bone formation in sides treated with the SF-BC composite plate, and bony defects were completely healed within 8 weeks.
CONCLUSIONS
The SF-BC composite plate is a potential candidate for a new bioresorbable fixation system. Our composite material could considerably shorten bone regeneration time. Additional study of the control of biodegradability and mechanical properties of SF-BC composite plates and a comparative study with the resorbable plates currently in use should be undertaken.
