[The study of rapid calculation on clearance creatinine rate in normal and epidemic hemorrhagic fever].

Height, weigh, urine volume/24 hours, serum creatinine (Scr) and urine creatinine were measured in 207 normal people and 232 patients with EHF. The clearance Creatinine rate (Ccr) was calculated by 24 hour urine volume method (therapy measure method) and Cockcroft's method (formulation method). The clearance creatinine rates between the two methods compared were significantly positive correlation, but the average values of Ccr in different stages in EHF were significantly different (P < 0.01). The result indicated that Cockcroft's Formulation was not fit for HFRS. According to the difference of Ccr in each stages of EHF, the adjustment values (ad) were presented and used to correct Cockcroft's formulation, thus, the adjusted Cockcroft's formulation could be obtained: Ccr = (140-ad-Age) x W/72 x Scr. In this paper, the Ccr of the adjusted method was compared with that of therapy measure method, the average values calculated by two methods were not different (P > 0.05). The result of 14 EHF Clinic practice demonstrated that between adjustment and practice measured methods were not significantly different. It shows that adjustment method is practical and available and can be used easily by clinic doctors in basic hospital.