Association of calorie and carbohydrate intake with tumour grade in early diagnosis of breast cancer: a case-control study.

Background: This study aimed to investigate the association of calorie and carbohydrate intake with tumour grade in early detection of breast cancer (BC) in Iranian women.Materials and methods: This case-control study carried out on 62 women with high grade BC and 93 women with low grade BC. Information about confounding variables was collected through a questionnaire. Dietary intake of calorie and macronutrients was assessed by a valid 122-item semi-quantitative food frequency questionnaire.Results: Individuals with high grade BC had significantly lower calorie (0.16, 0.04-0.61) and higher carbohydrate intake (4.02; 1.28-12.63) compared with those with low grade BC after controlling for age. This correlation remained significant after adjusting for confounding factors.Conclusion: Our results showed that lower intakes of calorie and higher carbohydrate are directly related to the high grade of tumour at the early detection of people with BC after modifying a wide range of confounding factors.