Thiol/Disulphide Homeostasis and Ischemia Modified Albumin Levels in Autoimmune Gastritis and Their Relations with Gastric Emptying.

Autoimmune gastritis is an autoimmune and inflammatory disorder. The aim of the study is to examine dynamic thiol/disulfide homeostasis, ischemia modified albumin levels and to analyze the association between thiol/disulfide homeostasis and gastric emptying time in autoimmune gastritis.Thiol/disulphide homeostasis tests and ischemia modified albumin levels were determined in 50 autoimmune gastritis patients and 53 healthy subjects. Patients with delayed and normal gastric emptying were compared by means of thiol/disulphide homeostasis tests.It has been seen that native thiol (?mol/L), total thiol (?mol/L) and native thiol/total thiol ratio (%) of the patients with autoimmune gastritis decreased compared to control group (177.7 ± 34.18 vs 245.25 ± 33.83, p=0.001 , 227.25 ± 36.78 vs 284.20 ± 27.19 , p = 0.03, and 8.84 ± 1.1 vs 7.74 ± 1.3%, p=0.001). In addition, native thiol (?mol/L), total thiol (?mol/L) and native thiol/total thiol ratio (%) were found to be lower in patients with delayed gastric emptying (198.65±24.27 vs 167.12±20.51, 241.81±27.14 vs 213.92±26.35, 8.34±1.29 vs 7.20±1.83, p=0.001). Disulphide level, disulphide/native thiol, disulphide/total thiol (p=0.001) ratios and ischemia modified albumin levels (ABSU, 0.71±0.08 vs 0.83±0.07) were found to be higher in autoimmune gastritis patients with delayed gastric emptying (p=0.001).It has been noted that thiol/disulphide homeostasis in patients with autoimmune gastritis has changed in the way that ischemia modified albumin and disulphide increased whereas thiols decreased. Altered thiol/disulphide balance was also observed in patients with delayed gastric emptying. These results have suggested that the oxidative process is involved in patients with autoimmune gastritis.