acetaldehyde/эпилептический припадок

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Epileptic Seizure Due to Disulfiram Treatment.

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Disulfiram has been used for the treatment of alcohol dependence for nearly 65 years and is approved by the Food and Drug Administration. It causes negative reinforcement by accumulating toxic acetaldehyde due to irreversible inhibition of aldehyde dehydrogenase. Disulfiram has very few side effects

[Effect of piracetam on some manifestations of the effects of ethanol and acetaldehyde].

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An experimental study of pyracetam (2-pyrrolidonacetamide) showed it capable to mitigate some behavioral and toxic manifestations of the action exerted by alcohol in tests on mice and rats, such as those of the "open field", "conflict situation", "rotating rod" and righting reflex. Pyracetam also

[Effect of several psychotropic agents on changes in the behavior of mice induced by acetaldehyde].

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Results of a study on the effect produced by 26 psychotropic agents on a complex set of behavioral changes in mice induced by introduction of acetaldehyde are presented. Experiments were conducted according to the method of Ortiz et al. (1973) who have proposed this test as a model of the abstinence

State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats.

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In Experiment 1, twelve Sprague-Dawley rats were trained in a two-choice food-reinforced drug discrimination task (10-min sessions) using the state-dependent interoceptive stimulus attributes of ethanol's (ETOH) delayed or rebound effects (EDE) versus "normal" basal homeostasis. Rats were injected

Acute dependence on depressant drugs is determined by common genes in mice.

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Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WRS) mice were genetically selected to express severe or mild handling-induced convulsions (HIC), respectively, after cessation of chronic ethanol (EtOH) vapor inhalation. The studies reported here tested WSP and WSR mice to determine

Absence of formation of brain salsolinol in ethanol-dependent mice.

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The in vivo biosynthesis of tetrahydroisoquinoline (TIQ) alkaloids has been shown to occur during acute and chronic ethanol administration under experimental conditions which increase aldehyde precursors and reduce TIQ metabolism. The TIQs have been postulated to mediate some of the effects of

[Alcohol dependence: diagnosis and treatment].

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OBJECTIVE Prevalence of alcohol dependence remains stable across time between 5-7% in men and 2-3% in women, corresponding to at least 1.5 million patients in France. A review about alcohol dependence is warranted, not only as prevalence of this disease is high, but also because of recent

Impairment of avoidance behavior following short-term ingestion of ethanol, tertiary-butanol, or pentobarbital in mice.

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Acquisition of a shock avoidance task was impaired in mice after cessation of chronic consumption of ethanol, tertiary-butanol (t-butanol), or pentobarbital. The drugs were administered in liquid diets for 7 days after withdrawal of the drugs. The avoidance deficit was also observed 8 days after

[Value of electroencephalographic studies for the evaluation of the neurotoxic effect of metallic mercury].

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The results of 373 EEG investigations were analysed. They were obtained in a period of 4 years in 222 workers with occupational exposure to metallic mercury in the synthesis of acetaldehyde and salt electrolysis. Abnormal or borderline abnormal results were found in 13% of them. Results were

Acute metaldehyde poisoning in Taiwan.

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Metaldehyde, a cyclic tetramer of acetaldehyde, is a widely used molluscicide. Although cases with acute metaldehyde poisoning have been reported, the occurrence of severe poisoning is uncommon. To provide more information on human metaldehyde poisoning, we reviewed 15 cases of metaldehyde exposure

Adsorption effects of activated charcoal on metaldehyde toxicity in rats.

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Metaldehyde has been widely used as a main ingredient of solid fuel for making fire and slug baits in Japan. It is also marketed as a color flame tablet for party goods (ENGELFIRE). Consequently, children have been poisoned by eating such tablets which they mistook for candy. As a result, poison

Final report of the safety assessment of Alcohol Denat., including SD Alcohol 3-A, SD Alcohol 30, SD Alcohol 39, SD Alcohol 39-B, SD Alcohol 39-C, SD Alcohol 40, SD Alcohol 40-B, and SD Alcohol 40-C, and the denaturants, Quassin, Brucine Sulfate/Brucine, and Denatonium Benzoate.

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Alcohol Denat. is the generic term used by the cosmetics industry to describe denatured alcohol. Alcohol Denat. and various specially denatured (SD) alcohols are used as cosmetic ingredients in a wide variety of products. Many denaturants have been previously considered, on an individual basis, as

Determination of paraldehyde by gas chromatography in whole blood from children.

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A rapid, sensitive and selective gas chromatographic method with flame ionization detection was developed for the determination of paraldehyde in small blood samples taken from children. Whole blood samples (300 microl) collected in a 3 ml Wheaton glass sample vial were spiked with acetone (internal

Poisoning by Gyromitra esculenta--a review.

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Gyromitra esculenta (Pers.: Fr.) Fr. and a few other mushrooms have caused severe poisonings and even deaths in humans. Clinical data are characterized primarily by vomiting and diarrhoea, followed by jaundice, convulsions and coma. Gastrointestinal disorders distinguish this poisoning. Frequent

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