Patients receive nicotine-free and flavor-free electronic cigarettes and instructed to use them BID over a 2 hour period for 4 weeks.
Patients undergo a second bronchoscopy during week 5.

Patients receive no intervention.
Patients undergo a second bronchoscopy during week 5.

Patients undergo bronchoscopy of the left lung over 30-60 minutes.

Patients undergo bronchoscopy of the right lung over 30-60 minutes.

Current Smoker

Never Smoker

Tobacco Use Disorder

Former Smoker

E-cig User

Bronchoscopy

Given nicotine-free and flavor-free electronic cigarettes

Electronic Cigarette

Laboratory Biomarker Analysis

Questionnaire Administration

Ohio State University Comprehensive Cancer Center

Effects of Electronic Cigarette Use on the Lungs

Effects of Electronic Cigarette Use on the Human Lung

Using bronchoalveolar lavage, and bronchial brushings for gene expression use patterns and biomarkers will be assessed and compared between two groups (e.g., non-smokers vs. smokers). For univariable comparisons, non-parametric methods such as the Kruskal-Wallis H-test for more than two independent groups and the Mann Whitney U-test for two independent groups will be used. Group associations controlling for possible confounders or effect modifiers will be explored using multiple linear regression models.

Descriptive statistics and plots will be used to informally assess changes in biological parameters between bronchoscopies; repeated measures models may be used to control for possible confounding between the groups as well as provide estimates for future power calculations.

acrolein/кариес зубов

Effects of Electronic Cigarette Use on the Lungs

Самая полная база данных о лекарственных травах, подтвержденная наукой