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More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine.

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Amphetamine is a stimulant drug that enhances attention and feelings of alertness. Amphetamine's effects are known to be modulated by endogenous cannabinoids, which are degraded by the enzyme fatty acid amide hydrolase (FAAH). In this study we investigated inter-individual differences in mood

[Amide groups of brain and spinal proteins in acute and chronic alcohol intoxication].

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Acute and chronic alcohol intoxication causes a considerable deamidation of central nervous system proteins which is most pronounced in the spinal cord. There occurs rearrangement in the amide bonds lability and in the ratio of easy-hydrolyzable and strongly bound amide groups. The metabolic

Mechanisms of bioprosthetic heart valve failure: fatigue causes collagen denaturation and glycosaminoglycan loss.

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Bioprosthetic heart valve (BPHV) degeneration, characterized by extracellular matrix deterioration, remodeling, and calcification, is an important clinical problem accounting for thousands of surgeries annually. Here we report for the first time, in a series of in vitro accelerated fatigue studies

Secondary structural changes of proteins in fingernails of chronic fatigue syndrome patients from Fourier-transform infrared spectra.

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BACKGROUND Generally, nails can be an index of health, with abnormalities sometimes found under diseased conditions. Fatigue is also supposed to affect the condition of nails. Possible differences in infrared (IR) spectra of nail plates of chronic fatigue syndrome (CFS) patients compared to healthy

Amide- and urea-functionalized dithienylethene: synthesis, photochromism, and binding with halide anions.

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A versatile amide- and urea-functionalized dithienylethene has been successfully synthesized. Upon irradiation with UV or visible light, the compound showed excellent fatigue resistance. As a synthetic receptor, the dithienylethene displayed switchable affinities for Cl(-) and Br(-) anions when the

Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue.

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Reactions involving thiol biochemistry seem to play a crucial role in skeletal muscle fatigue. N-acetylcysteine amide (NACA) and L-ergothioneine (ERGO) are thiol-based antioxidants available for human use that have not been evaluated for effects on muscle fatigue. OBJECTIVE To test the hypothesis

Modelling of serotonin reuptake inhibitory and histamine H₃antagonistic activity of piperazine and diazepane amides: QSAR rationales for co-optimization of the activity profiles.

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Selective human serotonin reuptake transporter (hSERT) inhibition is the first line of treatment to deal with the depression. In clinical practice for managing depression, the stimulants are co-prescribed to overcome cognitive impairment and fatigue. Recently, histamine H(3) antagonists with

Analysis of lysergic acid amide in human serum and urine after ingestion of Argyreia nervosa seeds.

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The ergot alkaloid lysergic acid amide (LSA) is a secondary plant constituent in a number of plants, but it is mainly present in considerable amounts in Convolvulaceae, like Argyreia nervosa. Due to its close structural similarity to lysergic acid diethylamide, LSA is considered as psychedelic and

Cobalt Amide Imidate Imidazolate Frameworks as Highly Active Oxygen Evolution Model Materials.

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Two imidazolate-based Co-MOFs, IFP-5 and IFP-8 (imidazolate framework Potsdam), with a different peripheral group -R (-Me and -OMe, respectively) have been synthesized by a solvothermal method and tested toward the oxygen evolution reaction (OER). Remarkably, IFP-8 presents much lower overpotentials

[Phase-II-study with vindesine (desacetyl-vinblastine-amide-sulfate) in advanced malignant diseases].

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53 patients with advanced and measurable cancerr were treated with vindesine in doses of 3 mg/m2 (pretreated) and 4 mg/m2 (non pretreated) i.v. once weekly. 48 patients are evaluable for response: of 14 patients with squamous cell carcinoma of the lung, 1 partial remission (PR), 1 minor response

The potential role of B5: A stitch in time and switch in cytokine.

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The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic

Reversible photochromic system based on rhodamine B salicylaldehyde hydrazone metal complex.

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Photochromic molecules are widely applied in chemistry, physics, biology, and materials science. Although a few photochromic systems have been developed before, their applications are still limited by complicated synthesis, low fatigue resistance, or incomplete light conversion. Rhodamine is a class

Growth inhibition and apoptosis of human multiple myeloma cells induced by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid derivatives.

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Multiple myeloma is a blood cell cancer and can cause symptoms such as bone loss and fatigue. Recent studies have shown that the bone marrow microenvironment may mediate tumor proliferation, drug resistance, and migration of the multiple myeloma cells. Synthetic triterpenoids have been used for the

Low doses of arginine butyrate derivatives improve dystrophic phenotype and restore membrane integrity in DMD models.

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A new approach to treating Duchenne muscular dystrophy was investigated by using the ester or amide covalent association of arginine [nitric oxide (NO) pathway] and butyrate [histone deacetylase (HDAC) inhibition] in mdx mice and patient myotubes. Two prodrugs were synthesized, and the beneficial

Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection

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Fibromyalgia is a rheumatologic condition characterized by multiple and chronic body pain, and other typical symptoms such as intense fatigue, anxiety and depression. It is a very complex disease where treatment is often made by non-medicated alternatives in order to alleviate symptoms and improve

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