asthenia/злокачественная опухоль

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Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function.

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OBJECTIVE Muscle wasting in cancer negatively affects physical function and quality of life. This study investigates amino acid metabolism and the association with muscle mass and function in patients with cancer. METHODS In 16 patients with advanced cancer undergoing chemotherapy and 16 healthy

Methylphenidate in the management of asthenia in breast cancer patients treated with docetaxel: results of a pilot study.

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BACKGROUND The objectives of this pilot study were to evaluate the safety and efficacy of the central nervous system stimulant methylphenidate in the management of asthenia in breast cancer patients treated with docetaxel. METHODS Patients with early breast cancer who presented asthenia >3 on the

Relationship between weakness and phase angle in advanced cancer patients with fatigue.

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OBJECTIVE This study aims to determine the relationship between weakness and bioimpedance analysis (BIA)-derived phase angle in a population of untreated cancer patients with fatigue. METHODS We prospectively evaluated 41 treatment-naive cancer patients of several origins that presented with

Redefining cancer-related asthenia-fatigue syndrome.

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BACKGROUND Asthenia fatigue syndrome (AFS) is a common symptom perceived by patients with cancer and consists of reported pathologic fatigue, poor endurance, and impaired motor and cognitive function. OBJECTIVE The purpose of this study was to examine the relationship between a traditional measure

[Intramedullary spinal cord tumour as differential diagnosis to bilateral muscle weakness].

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Intramedullary spinal cord tumours (IMSCT) are rare neoplasms, which can potentially lead to severe neurologic deficits. In this case report, an 83-year-old man presented with rapidly progressive bilateral muscle weakness developed within few weeks. MRI revealed a spinal cord tumour at the C7/Th1

[CR of All Target Lesions in a Patient with Metastatic Esophageal Cancer and Generalized Weakness Treated with Systemic Chemotherapy after Nutritional Support].

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We report here a case of CR of all target lesions in a patient with esophageal cancer with multiple metastases treated with systemic chemotherapy after nutritionalsupport. A 75-year-old man was referred to our hospital with a diagnosis of multiple- metastatic esophagealcancer in June 2014. He showed

[A patient with an ACTH-releasing thymic carcinoid tumor presenting with proximal muscle weakness].

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We report a 36-year-old man with proximal dominant muscle weakness, thymic tumor, diabetes mellitus, hypokalemia, and increased levels of plasma ACTH and cortisol. The diagnosis of carcinoid tumor was made on the basis of pathological findings in the biopsied specimen of the thymic tumor. The

Weakness in malignancy: evidence for a remote effect of tumor on distal axons.

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Malignant tumors are known to have a "remote" or nonmetastatic effect on the central and peripheral nervous systems. Eight patients were seen with proximal muscle weakness in association with bronchogenic carcinoma (5), carcinoma of breast (2), and leukemia (1). Electromyography demonstrated small

Association between asthenia and nutritional status, lean body mass, anemia, psychological status, and tumor mass in patients with advanced breast cancer.

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Sixty-four consecutive patients with advanced breast cancer were included in a study designed to determine the prevalence of asthenia and its association with other clinical features. The Asthenia Score (AS, the average of four tests designed by our group to assess asthenia) was 59 +/- 9 for

Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: involvement of muscle myofilaments.

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The respiratory and limb skeletal muscles become weakened in sepsis, congestive heart failure, and other inflammatory diseases. A potential mediator of muscle weakness is tumor necrosis factor (TNF)-alpha, a cytokine that can stimulate muscle wasting and also can induce contractile dysfunction

[Asthenia in advanced cancer and the use of psychostimulants].

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Asthenia is the most frequent symptom in patients with advanced cancer and is probably what most affects the quality of life of oncology patients since it interferes in their physical and social activity. Treatment in the majority of cases is symptomatic. There is growing interest in the use of

Mandibular tumor-induced muscular weakness and osteomalacia.

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The case presented is that of a 26-year-old man who suffered from muscular weakness and aching pains 2 years prior to hospitalization. During that period, a tumor in the mandible was diagnosed. During the neurologic work-up to find the cause of the muscular weakness, the possibility of a metabolic

Convergence Weakness with Intact Medial Rectus Function in Proptosis due to Orbital Tumors

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Background: The pathway underlying ocular convergence is less clear. Convergence weakness is usually a clinical sign of dorsal midbrain pathology. An orbital tumor causing such phenomenon is unknown. We describe its occurrence in patients

Analysis of factors related to arm weakness in patients with breast cancer-related lymphedema.

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OBJECTIVE The aim of this study was to evaluate the ratio of significant weakness in the affected arm of breast cancer-related lymphedema patients to their unaffected side. Another purpose was to identify factors related to arm weakness and physical function in patients with breast cancer-related

An infarcted Warthin's tumour presenting with facial weakness.

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It is rare for benign salivary gland neoplasms to cause facial nerve weakness. We present such a case occurring in a 70-year-old patient with an infarcted Warthin's tumour and review the benign causes of facial nerve impairment.

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