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ataxia/злокачественная опухоль
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Predisposition to breast cancer by mutations at the ataxia-telangiectasia genetic locus
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BACKGROUND OF THE INVENTION
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to the discovery that some alleles of the A-T gene cause susceptibility to cancer, in particular breast cancer. More specifically, the present invention
Systems and methods for diagnosing a predisposition to develop colon cancer
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REFERENCE TO A SEQUENCE LISTING
This application includes a Sequence Listing submitted electronically as a text file named CC Genomic Instability_ST25.txt, created on Mar. 10, 2013 with a size of 180,000 bytes. The Sequence Listing is incorporated by reference herein.
FIELD OF THE INVENTION
The
Inhibiting ataxia telangiectasia and Rad3-related protein (ATR)
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FIELD
This disclosure relates to compounds and related methods of inhibiting ataxia telangiectasia and Rad3-related protein (ATR), including methods and compounds useful for the treatment of cancer.
BACKGROUND
The ataxia-telangiectasia and Rad3-related (ATR) kinase is a serine/threonine protein
Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to: (i) chemical compounds that are generally useful as pharmaceutically active agents, and in particular as ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors; (ii) pharmaceutical compositions comprising one or more of these ATR
Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to: (i) chemical compounds that are generally useful as pharmaceutically active agents, and in particular as ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors; (ii) pharmaceutical compositions comprising one or more of these ATR
Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to: (i) chemical compounds that are generally useful as pharmaceutically active agents, and in particular as ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors; (ii) pharmaceutical compositions comprising one or more of these ATR
Detection of anti-neurochondrin autoantibody in patients with cerebellar ataxia or cerebellitis
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RELATED APPLICATIONS
This application claims the benefit of European Patent Application No. 15001186.4, filed Apr. 22, 2015, which is hereby incorporated by reference in its entirety.
SUMMARY
The present disclosure relates to methods for diagnosing a disease, for example, a disease associated with
Use of tempol for the treatment of Li-Fraumeni syndrome and ataxia telangiectasia
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FIELD OF THE INVENTION
The present invention relates to nitroxides and prodrugs thereof and their use in the prophylactic and therapeutic treatment of cancer.
BACKGROUND OF THE INVENTION
Cancer is a major world-wide health problem. Given that the vast majority of human tumors are difficult to treat
Human I.kappa.B-.beta.
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FIELD OF INVENTION
This invention relates to newly identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the I.kappa.B
Fluorinated derivates of 3-hydroxypyridin-4-ones
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BACKGROUND
The occurrence of in vivo iron toxicity in the human body can be categorized into iron overload and non-iron overload conditions. Iron overload conditions are common in thalassaemia patients through chronic blood transfusions and in hereditary haemochromatosis patients. Non-iron
Fluorinated derivatives of 3-hydroxypyridin-4-ones
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BACKGROUND
The occurrence of in vivo iron toxicity in the human body can be categorized into iron overload and non-iron overload conditions. Iron overload conditions are common in thalassaemia patients through chronic blood transfusions and in hereditary haemochromatosis patients. Non-iron
Fluorinated derivatives of 3-hydroxypyridin-4-ones
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BACKGROUND OF THE INVENTION
The occurrence of in vivo iron toxicity in the human body can be categorized into iron overload and non-iron overload conditions. Iron overload conditions are common in thalassemia patients through chronic blood transfusions and in hereditary hemochromatosis patients.
Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Sep. 17, 2015, is named UCH-01202_SL.txt and is 33,119 bytes in size.
FIELD OF THE
Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life
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FIELD OF THE INVENTION
This invention relates to using intestinal bacteria to modify lymphoma penetrance and inflammation-mediated genotoxicity.
BACKGROUND OF THE INVENTION
Ataxia-telangiectasia (A-T) is an autosomal recessive disorder associated with high incidence of lymphoid malignancies,
Inhibitors of transcription factor-NF-.kappa.B
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FIELD OF THE INVENTION
This invention relates in general to salicylanilide inhibitors of transcription factor NF-.kappa.B. Such compounds are particularly useful for treating diseases in which activation of NF-.kappa.B is implicated. More specifically, these compounds inhibit I.kappa.B
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