Alzheimer's Disease

Obstructive Sleep Apnea

Hospital santa Maria

Hospital Santa Maria Lleida

Role of Hypoxia Ans Sleep Fragmentation in Alzheimer's Disease. and Sleep Fragmentation.

Impact of Obstructive Sleep Apnea in the Evolution of Alzheimer Disease. Role of Hypoxia and Sleep Fragmentation

For this objective we will recruit consecutively 72 patients with OSA and another 72 patients without OSA from the same population of patients with mild initial AD. We will use extensive neuropsychological battery at baseline and at 12 month and polysomnography (PSG) to select both groups of patients at baseline.

For this objective we will use CSF (ELISA will be employed to detect the levels of hypoxia-inducible factor 1-alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF); and CSF biomarkers of AD as AB42, tau and phosphotau. Lipidaemic and metabolomic analyses will be performed on both, blood sample and CSF. Brain MRI (hippocampal volume, specific patterns of cerebral perfusion and spectroscopy) and actigraph registry. Blood samples to determine inflammatory markers (TNF-alpha, Interleukine-6 and Interleukine-8), the Thiobarbituric Acid Reactive Substances (TBARS) and genotyping APOE4 will be preformed. We will analyze the correlation of these biological biomarkers with cognitive and behavioural progression in OSA and non-OSA AD patients.

Ferran Barbe

Sociedad Española de Neumología y Cirugía Torácica

chloroform

hypoxia

chloroform/hypoxia

Role of Hypoxia Ans Sleep Fragmentation in Alzheimer's Disease. and Sleep Fragmentation.

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