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Changes in biliary lipid secretion and cholic acid kinetics induced by diet, diet plus simvastatin and diet plus ursodeoxycholic acid in obese subjects.

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The aim of this work was to evaluate and compare the effects of a low calorie diet (1026 kcal), simvastatin and ursodeoxycholic acid administration on biliary lipid secretion and cholic acid kinetics in dieting obese subjects. We studied 6 obese subjects before and after four weeks of a hypocaloric

Serum insulin levels in non-obese, non-diabetic Asian Indians with acute coronary and non-coronary events.

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Significant insulin resistance and hyperinsulinemia has been observed to be associated with coronary heart disease in epidemiological studies, particularly so in Asian Indians. This study attempted to investigate if hyperinsulinemia accompanies acute cardiovascular events in Asian Indians, and that

Stapler division of the omentum and small bowel mesentery in morbidly obese patients undergoing gastric bypass surgery.

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BACKGROUND Roux-en-Y gastric bypass (RYGB) procedures can be technically demanding because of anatomical factors including fat distribution, organ fixation, and wound depth. We developed a technique using the Multifire Endo GIA 60 2.5 disposable surgical stapler which allows greater mobilization,

[Historical development of the surgical treatment of gross obesity].

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Reference is made to the experimental preliminary remark and the first, clinical observations underlying the surgical management of severe obesity, together with the techniques employed, starting with the jejunal-colic by-pass of Payne et al. This, however, led to serious liver damage and

Gastro-colic fistula secondary to benign gastric ulceration.

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An 80-year-old woman developed osteoarthritis of the knees as a complication of her obesity. Indomethacin treatment precipitated gastric ulceration, which led to the formation of a gastro-colic fistula.

Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs.

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OBJECTIVE We have recently established a novel swine model for studies of atherosclerosis using MicrominipigsTM (µMPs) fed a high-fat/high-cholesterol diet (HcD). Using this swine model, we re-evaluated the effects of dietary cholic acid (CA) on serum lipid profile, atherosclerosis and hepatic

[Dynamics of changes in the lipid composition of bile in patients with alimentary obesity during treatment].

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In the bile of patients with alimentary obesity, the content of primary (cholic) bile acids is reduced, that of secondary (deoxycholic) acids is increased, and the quota of glycine-bound cholates is lowered. This points to the distress of the cholate-synthesizing, glyco-conjugating, and

Hypoglycemic effects of colestimide on type 2 diabetic patients with obesity.

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Recent studies have shown colestimide, a bile acid-binding resin, to also exert a glucose-lowering effect via amelioration of insulin resistance. To evaluate the effects of colestimide on glucose metabolism and to elucidate the underlying mechanism, we conducted a 6-month, open-label pilot study on

Functional abdominal pain syndrome in morbidly obese patients following laparoscopic gastric bypass surgery.

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BACKGROUND Roux-en-Y gastric bypass surgery (RYGBP) is one of the most common bariatric surgeries, which is being performed using various techniques like gastrojejunostomy by hand swen, linear or circular stapler. Abdominal pain is a common complaint following laparoscopic gastric bypass procedure

Low-dose CT with automatic tube current modulation, adaptive statistical iterative reconstruction, and low tube voltage for the diagnosis of renal colic: impact of body mass index.

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OBJECTIVE The objective of our study was to evaluate the impact of body mass index (BMI) on dose, diagnostic performance, and image quality of a low-dose CT examination for renal colic. METHODS This retrospective study included all patients who underwent a low-dose CT examination for renal colic

The impact of body mass on management of patients with renal colic.

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OBJECTIVE To study the impact of body mass on diagnosis and initial response to medical treatment in patients presenting with renal colic. METHODS One hundred and sixty-five consecutive patients presenting with symptoms of renal colic have been examined. Patients were divided in 3 groups according

The mechanism of increased gallstone formation in obese human subjects.

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Cholesterol gallstones occur three times more frequently in morbidly obese subjects than in normal controls. The present study tests the hypothesis that obese subjects develop gallstones because of relative and absolute excess cholesterol excretion in bile. The steady-state kinetics of biliary lipid

Effects of feeding cholic acid and chenodeoxycholic acid on cholesterol absorption and hepatic secretion of biliary lipids in man.

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Chenodeoxycholic acid (CDCA), in contrast to cholic acid (CA), reduces cholesterol saturation of bile. The mechanisms for these differences were the object of this study. Investigations were carried out in nine white men; three nonobese subjects and one obese subject were fed a weight-maintenance

Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis.

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UNASSIGNED We tested the hypothesis that fecal microbiota transplantation (FMT) could regulate the biotransformation of bile acids, such as deoxycholic acid (DCA) and cholic acid (CA), which in turn regulate the biosynthesis of serotonin in the gut and relieve gastrointestinal dysmotility in

Lipid composition of bile in morbid obesity before and after jejunoileal bypass surgery.

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Bile cholesterol, phospholipids, total bile acids, individual bile acids, and fatty acid compositions of bile neutral lipids and phospholipids were analyzed before, at one month and at six months following jejunoileal bypass surgery in a series of morbidly obese patients. Preoperative mole

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