colorectal neoplasms/никотин

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VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer.

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The biological role of vacuolar protein sorting 33B (VPS33B) has not been examined in colorectal cancer (CRC). We report that VPS33B was downregulated in dextran sulfate sodium/azoxymethane (DSS/AOM) -induced CRC mice models and nicotine-treated CRC cells via the PI3K/AKT/c-Jun pathway. Reduced

Prospective study of NAT1 and NAT2 polymorphisms, tobacco smoking and meat consumption and risk of colorectal cancer.

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Heterocyclic amines in tobacco smoke and fried meat are activated or detoxified by N-acetyltransferases (NAT1 and NAT2). We identified 379 cases with colorectal cancer (CRC) and 769 sub-cohort members among a cohort of 57,000 members. There were no statistically significant associations between

Nicotine downregulates microRNA-200c to promote metastasis and the epithelial-mesenchymal transition in human colorectal cancer cells.

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BACKGROUND Cigarette smoking is the most well-established risk factor for colorectal cancer (CRC). However, the mechanisms of smoking-associated colorectal carcinogenesis are poorly understood. METHODS The effects of prediagnosis tobacco use on clinical characteristics, overall survival (OS), and

Tobacco smoking: a factor of early onset of colorectal cancer.

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OBJECTIVE Tobacco smoking is associated with a higher risk of developing colorectal cancer. This study was designed to assess the role of smoking in early onset of colorectal pathology. METHODS This was a prospective cross-sectional study of 997 patients with colorectal cancer. Age of colorectal

Tobacco smoking and colorectal cancer: a population-based case-control study in Newfoundland and Labrador.

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OBJECTIVE Newfoundland and Labrador (NL) has the highest incidence rate of both colorectal cancer (CRC) and smoking prevalence in Canada. The objective of this study was to examine if CRC is associated with smoking in this population. METHODS Newly diagnosed cases identified between 1999 and 2003

Association of tobacco and alcohol use with earlier development of colorectal cancer: should we modify screening guidelines?

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BACKGROUND Current guidelines recommend initial colorectal cancer screening at age 50 years for average-risk patients. Alcohol and tobacco use can be associated with earlier onset of colorectal cancer. We hypothesized an earlier age at diagnosis and/or more advanced stage in patients with these

Long-term tobacco smoking and colorectal cancer in a prospective cohort study.

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Tobacco smoking has consistently been associated with colorectal adenomas, precursors of cancer, but the association with colorectal cancer itself has not been consistent. If colorectal cancer emerges only after a 35-year induction period, an association would unlikely be detected in studies where

Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany.

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In a population-based case-control study in Germany, 540 incident cases of colorectal cancer (CRC) aged > or =30 years and 614 controls were recruited from January 2003 to June 2004. Information on risk factors of CRC and lifetime history of active smoking and exposure to environmental tobacco smoke

Metabolites of tobacco smoking and colorectal cancer risk.

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Colorectal cancer is not strictly considered a tobacco-related malignancy, but modest associations have emerged from large meta-analyses. Most studies, however, use self-reported data, which are subject to misclassification. Biomarkers of tobacco exposure may reduce misclassification and provide

Tobacco, colorectal cancer, and adenomas: a review of the evidence.

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Although tobacco has been clearly implicated as a cause of a number of cancers, earlier studies had not generally found cigarette smokers to be at higher risk for cancers of the large bowel. Unlike the earlier studies, more recent studies have tended to find cigarette smokers to be at higher risk of

Tobacco smoking and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population.

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BACKGROUND It is unclear whether tobacco smoking is related to colorectal cancer risk in Japan. We evaluated the association among the Japanese population based on a systematic review of epidemiologic evidence. METHODS Original data were obtained from searches of MEDLINE using PubMed, complemented

Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome).

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BACKGROUND The marked variability in age at onset of colorectal cancer (CRC) in patients with hereditary nonpolyposis colorectal cancer (HNPCC) makes management decisions difficult. Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been

NQO1 609C>T polymorphism interaction with tobacco smoking and alcohol drinking increases colorectal cancer risk in a Chinese population.

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BACKGROUND NAD (P)H:quinone oxidoreductase (NQO1) catalyzes the activation of some environmental procarcinogens present in tobacco smoke or the diet. We conducted a hospital-based case-control study to evaluate the potential association between NQO1 609C>T polymorphisms and colorectal cancer risk in

Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.

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N-Acetyltransferases 1 and 2 (NAT1 and NAT2), both being highly polymorphic, are involved in the metabolism of aromatic and heterocyclic aromatic amines present in cigarette smoke and red meat cooked by high-temperature cooking techniques. We investigated the effect of differences in acetylation

Smokeless tobacco (snus) use and colorectal cancer incidence and survival: Results from nine pooled cohorts.

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OBJECTIVE Although smoking is considered to be an established risk factor for colorectal cancer, the current evidence on the association between smokeless tobacco and colorectal cancer is scant and inconclusive. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus

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