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histone/воспаление
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Compositions for anti-inflammatory, antioxidant effects and improved respiratory function by specific histone deacetylase inhibition
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FIELD OF THE INVENTION
The invention relates to compositions comprising L-sulforaphane (LSF) and to treatment regiments comprising L-sulforaphane (LSF) compositions. Compositions and/or regiments may optionally include the administration of vitamins, minerals, and/or anti-oxidants. Methods for using
Method for treating rheumatoid arthritis with composition containing histone
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TECHNICAL FIELD
The present invention relates to the use of histone H1 in improving inflammatory symptoms of arthritis. Histone H1 lowers an induction of arthritis and reduces arthritis index more effectively than conventional drugs and also has a significant preventive effect.
BACKGROUND OF THE
Inhibitors of histone methyltransferase G9a
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FIELD OF THE INVENTION
The present invention relates to inhibitors of histone methyltransferases G9a and GLP directed to treatment of cancer, inflammation, and autoimmune disease.
BACKGROUND
Histone methyltransferases (HMTs), a class of enzymatic "writers" of epigenetic marks, have recently emerged
Histone deacetylase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to hydroxamic acid derivatives having a sulfonamide linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and
Histone deacetylase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to iminodiacetic acid and diamine hydroxamic acid derivatives, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and
Histone deacetylase inhibitors
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BACKGROUND OF THE INVENTION
This invention relates to hydroxamic acid derivatives having a carbamate linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and
Histone H2A peptide derivatives and uses thereof
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FIELD OF INVENTION
The present invention relates to peptide derivatives and analogs comprising the amino acid sequence of a fragment of mammalian histone H2A and to pharmaceutical compositions comprising same. The compositions of the invention are useful for treating inflammatory, autoimmune and
Chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Chimeric and humanized anti-histone antibodies
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FIELD OF THE INVENTION
The invention relates to compositions and methods of use of anti-histone antibodies or antigen-binding fragments thereof. In particular embodiments, the antibodies bind to human histones H2B, H3 or H4. The anti-histone antibodies are of use for diagnosis and/or therapy of a
Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates generally to the fields of autoimmunity and inflammatory bowel disease and more specifically to the diagnosis and treatment of a clinical subtype of ulcerative colitis.
2. Background Information
Inflammatory bowel disease
Inhibitors of histone deacetylase
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FIELD OF THE INVENTION
The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. These compounds are useful for treating, alleviating,
Inhibitors of histone deacetylase
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FIELD OF THE INVENTION
The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. These compounds are useful for treating, alleviating,
Inhibitors of histone deacetylase
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FIELD OF THE INVENTION
The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. These compounds are useful for treating, alleviating,
Inhibitors of histone deacetylase
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FIELD OF THE INVENTION
The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. These compounds are useful for treating, alleviating,
Compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same
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This application is a 371 of PCT/KR2015/002417, filed on Mar. 12, 2015, which claims priority to Korean patent application number 10-2014-0028920, filed on Mar. 12, 2014.
TECHNICAL FIELD
The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity,
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