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14 полученные результаты
Methods for treating ischemic stroke using chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Chimeric and humanized anti-histone antibodies
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FIELD OF THE INVENTION
The invention relates to compositions and methods of use of anti-histone antibodies or antigen-binding fragments thereof. In particular embodiments, the antibodies bind to human histones H2B, H3 or H4. The anti-histone antibodies are of use for diagnosis and/or therapy of a
Heterocycle derivatives as histone deacetylase (HDAC) inhibitors
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PRIORITY CLAIM
This application is a .sctn.371 National Stage Application of PCT/GB2005/004743, filed on Dec. 9, 2005, which claims priority from GB Provisional Application Serial Numbers 0516435.5, filed on Aug. 11, 2005, and 0427138.3, filed on Dec. 10, 2004.
The present invention relates to
Nucleic acids encoding chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors
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FIELD OF THE INVENTION
The present invention relates to histone deacetylase inhibitors (HDACIs), to pharmaceutical compositions comprising one or more of the HDACIs, to methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy comprising
Methods for treating thrombosis using chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Methods for treating sepsis using chimeric and humanized anti-histone antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size.
FIELD OF THE
Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors
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The present invention relates to thiophene and thiazole substituted trifluoroethanone derivatives which are inhibitors of histone deacetylase (HDAC), particularly class II HDAC. The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further,
Heterocycle substituted amide and sulfur amide derivatives as histone deacetylase (hdac) inhibitors
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PRIORITY CLAIM
This application is a .sctn.371 National Stage Application of PCT/GB2006/050353, filed on Oct. 26, 2006, which claims priority from GB Provisional Application Serial Number 0522130.4, filed on Oct. 31, 2005.
BACKGROUND OF THE INVENTION
In eukaryotic cells the orderly packaging of DNA
Methods of treating rapidly progressive glomerulonephritis using chimeric and humanized anti-histone H4 antibodies
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1 SL.txt and is 71,342 bytes in size.
FIELD OF THE
Activators of class I histone deacetlyases (HDACs) and uses thereof
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FIELD OF THE INVENTION
The field of the invention pertains to activators of class I histone deacetylases and their uses in the treatment of neurological disorders.
BACKGROUND OF THE INVENTION
In a variety of neurodegenerative disorders such as ischemia and Alzheimer's disease (Hayashi et al.,
HDAC inhibitors and therapeutic methods of using same
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FIELD OF THE INVENTION
The present invention relates to histone deacetylase (HDAC) inhibitors, to pharmaceutical compositions comprising one or more of the HDAC inhibitors, to methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy
HDAC inhibitors and therapeutic methods using the same
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FIELD OF THE INVENTION
The present invention relates to histone deacetylase (HDAC) inhibitors, to pharmaceutical compositions comprising one or more of the HDAC inhibitors, to methods of increasing the sensitivity of cancer cells to the cytotoxic effects of radiotherapy and/or chemotherapy
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