hypospadias/ожирение

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Prepregnancy obesity as a risk factor for structural birth defects.

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OBJECTIVE To describe the relation between maternal obesity, overweight and underweight status, and 16 categories of structural birth defects. METHODS An ongoing multisite, case-control study. Clinical geneticists reviewed all of the cases, excluding those that had or were strongly suspected to have

Hypospadias associated undescended testis in a Spigelian hernia.

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BACKGROUND First described in 1764, Spigelian hernias are rare. The patient profile is of an overweight, 50-year-old with associated respiratory disease. However we report the case of a four-month-old, with an associated hypospadias and cryptorchidism, where the testis was lying in a spigelian

Maternal and gestational risk factors for hypospadias.

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BACKGROUND An increase in the prevalence of hypospadias has been reported, but the environmental causes remain virtually unknown. OBJECTIVE Our goal was to assess the association between risk of hypospadias and indicators of placental function and endogenous hormone levels, exposure to exogenous

[Urethral meatus deformities and urethra hypospadias in women: prevalence, problems and definitions. Study of 12,739 patients].

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The difficulty to access to the urethral meatus is found in women in relation to morphological abnormalities of urogenital or ectopic locations meatus, whether acquired (urethral meatus buried [UMB]) or congenital reality (urethra hypospadias [UH]). The pathophysiology is not unequivocal with lack

Severe forms of concealed penis without hypospadias: Surgical strategies.

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BACKGROUND Concealed penis (CP) may vary in severity and includes megaprepuce (MP) as a variant. Many different surgical strategies have been described in order to maximize penile exposure and to deal with skin deficiency. We describe the strategies that we use to overcome technical problems in

What is new in cryptorchidism and hypospadias--a critical review on the testicular dysgenesis hypothesis.

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It has been hypothesized that poor semen quality, testis cancer, undescended testis, and hypospadias are symptoms of one underlying entity--the testicular dysgenesis syndrome--leading to increasing male fertility impairment. Though testicular cancer has increased in many Western countries during the

Maternal obesity and morbid obesity: the risk for birth defects in the offspring.

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BACKGROUND The objective of this study was to assess, in a large data set from Swedish Medical Health Registries, whether maternal obesity and maternal morbid obesity were associated with an increased risk for various structural birth defects. METHODS The study population consisted of 1,049,582

Risk factors for different phenotypes of hypospadias: results from a Dutch case-control study.

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WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The various phenotypes of hypospadias may result from disturbances of dissimilar embryonic processes in different time windows, suggesting aetiological heterogeneity; however, only a few studies have investigated the risk factors for the

Maternal Smoking, Alcohol, and Caffeine Exposures and Risk of Hypospadias.

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BACKGROUND We examined the association of hypospadias risk with maternal smoking and consumption of alcohol and caffeine. METHODS We analyzed data from mothers of 2437 moderate/severe cases and 5472 nonmalformed controls born from 1997 to 2011 who participated in the National Birth Defects

Maternal Overweight and Obesity and Genital Anomalies in Male Offspring: A Population-Based Swedish Cohort Study.

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Overweight and obese pregnant women face higher risk of several critical birth outcomes, including an overall increased risk of congenital abnormalities. Only few studies have focused on associations between maternal overweight and the genital anomalies in boys, cryptorchidism and hypospadias, and

Male pseudohermaphroditism with persistent müllerian structures, mental retardation and Borjeson-Forssman-Lehmann-like features: a new syndrome?

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We report two sibs with an undescribed MCA/MR syndrome. Both had a 46,XY chromosome constitution. The first patient is profoundly mentally retarded. Clinical features include short stature, coarse face, deep set eyes, microphthalmia, large ears, gynecoid obesity, imperforate anus, sacral spina

Pediatric-adolescent andrology: Single centre experience

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Introduction: Andrology is the medical specialty dealing with men's health and reproductive system from birth to adulthood, including genital, hormonal, reproductive, sexual as well as psychological aspects; the aim of this study is to

McKusik Kaufman syndrome.

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A 12-years-old male child presented with polydactyly and syndactyly of hands, hypospadias, AND undescended testes. He was a known case of Tetrology of Fallot. One important differential in our case was Bardet-Biedl syndrome, but it was ruled out due to lack of evidence of central obesity, mental

Anesthesia for a 16-month-old patient with Prader-Willi syndrome.

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Prader-Willi syndrome (PWS) is a rare disorder of chromosome abnormalities in which the paternal genes in chromosome 15 are lacking. The clinical course is characterized by hypotonia, hyperphagia, and morbid obesity. Both general and regional anesthesia in these patients is difficult due to morbid

Maternal body mass index and congenital anomaly risk: a cohort study.

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OBJECTIVE To investigate the association between maternal body mass index (BMI) and major, structural congenital anomalies. METHODS Cohort study using prospectively collected data. METHODS Data on all singleton pregnancies booked at five maternity units in the north of England between 01 January

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