A monoclonal antibody against human manganese-superoxide dismutase characterized in that it is produced by a cell line which has been obtained by immunization of a mouse with human Mn-SOD and then fusion of lymphocytes obtained from the mouse with mouse myeloma cells, and has high specificity against human Mn-SOD; a method for producing a monoclonal antibody against human Mn-SOD having high specificity against human Mn-SOD, which comprises culturing the cell line obtained by immunization of a mouse with human Mn-SOD and then cell fusion of lymphocytes obtained from the mouse with mouse myeloma cells; a kit for assaying human Mn-SOD, comprising:(a) a monoclonal antibody having very high specific immuno-reactivity against human Mn-SOD; and(b) a reagent of a monoclonal antibody having very high specific immuno-reactivity against human Mn-SOD labelled with an enzyme (enzyme labelled antibody); a method for assaying human Mn-SOD use of the kit; a novel diagnostic method of human epithelial ovarian cancer, which comprises assaying the concentration of human Mn-SOD in a body fluid by use of the assay kit; and a novel diagnostic method of myocardial infarction, which comprises assaying the concentration of human Mn-SOD in a body fluid by use of the assay kit.

Ube Industries, Ltd.

Methods to screen for ovarian cancer and myocardial infarction

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1##wherein R, R', R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3, R'.sub.3, R.sub.4, R'.sub.4, R.sub.5, R'.sub.5, R.sub.6, R'.sub.6, R.sub.7, R'.sub.7, R.sub.8, R'.sub.8, R.sub.9, R'.sub.10, R.sub.10 and R'.sub.10, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, myocardial infarction, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.

manganese/инфаркт

Methods to screen for ovarian cancer and myocardial infarction

Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Самая полная база данных о лекарственных травах, подтвержденная наукой