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BACKGROUND OF THE INVENTION
Field of the Invention
The present invention relates generally to the field of diagnostic methods and biomarkers relating to myasthenia gravis. More specifically, the present invention relates to muscle specific tyrosine kinase-fluorophore conjugates compositions, kits
SEQUENCE LISTING
This application contains a Sequence Listing electronically submitted via EFS-Web to the United States Patent and Trademark Office as an ASCII text file entitled "275.00180120_SequenceListing_ST25 txt" having a size of 19.6 kilobytes and created on Dec. 8, 2015. The information
BACKGROUND
Myasthenia gravis is an autoimmune disease that causes dysfunction of the neuromuscular synapses. Seventy percent of patients with myasthenia gravis carry autoantibodies to the acetylcholine receptor (AChR) and a separate 10% carry autoantibodies to muscle specific tyrosine kinase (MuSK)
TECHNICAL FIELD
The present disclosure relates to a class of substituted hetero-bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts and pharmaceutical compositions containing them. The