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osteoarthritis/лихорадка
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Страница 1 от 22 полученные результаты
Substituted heteroaryl analogs of 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidine substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical
Compound WS 727713
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TECHNICAL FIELD
The present invention relates to a new compound which is useful as a medicament or a cosmetic, to a process for producing the same and to a pharmaceutical composition comprising the same.
BACKGROUND ART
The melanocortin (MC) is a group of peptide hormones that are derived from
Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
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BACKGROUND OF THE INVENTION
This invention relates to compounds and pharmaceutical compositions for the treatment of cyclooxygenase mediated diseases and methods of treating thereof.
Non-steroidal, antiinflammatory drugs exert most of their antiinflammatory, analgesic and antipyretic activity and
Substituted 4,6-di-tertiary-butyl 5-hydroxy-pyrimidines
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BACKGROUND OF THE INVENTION
The present invention is novel compounds which are 4,6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidine substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical
Compounds as inhibitor of tumor necrosis factor alpha release
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BACKGROUND OF THE INVENTION
Release of such cytokines as tumor necrosis factor a (TNF-.alpha.) and transforming growth factor .alpha. (TGF-.alpha.) can cause adverse reactions ranging from psoriasis to sepsis. Many of these reactions are related to inflammation or autoimmune conditions, such as
Hydrazine derivatives
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BACKGROUND OF THE INVENTION
Release of such cytokines as tumor necrosis factor .alpha.(TNF-.alpha.) and transforming growth factor .alpha.(TGF-.alpha.) can cause adverse reactions ranging from fever to sepsis. Many of these reactions are related to inflammation or autoinmuune conditions, such as
Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
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TECHNICAL FIELD
The present invention is directed to certain isoxazolone compounds that inhibit the release of inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells. The compounds of the invention, therefore, are useful in treating diseases involving unwanted
Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
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TECHNICAL FIELD
The present invention is directed to certain isoxazolone compounds that inhibit the release of inflammatory cytokines such as interleukin-1 (1L-1) and tumor necrosis factor (TNF) from cells. The compounds of the invention, therefore, are useful in treating diseases involving unwanted
Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors
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FIELD OF INVENTION
This invention relates to allenic aryl sulfonamide hydroxamic acids which act as inhibitors of TNF-.alpha. converting enzyme (TACE) and matrix metalloproteinase (MMP). The compounds of the present invention are useful in disease conditions mediated by MMP and TACE, such as
Substituted pyrido[2,3-d]pyrimidines as delta-5-desaturase inhibitors
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a U.S. national stage of International Application No. PCT/JP2011/066766 filed Jul. 22, 2011.
TECHNICAL FIELD
The present invention relates to a novel fused heterocyclic compound having superior properties as a medicament, and use thereof.
Pharmaceutical composition for preventing / treating TRPV1 activity-related and inflammation-related diseases or conditions containing maillard peptide separated from well-aged traditional soy sauce as active ingredient
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 371 of PCT/KR2010/007845, filed Nov. 8, 2010, which claims the benefit of Korean Patent Application No. 10-2009-0106912, filed Nov. 6, 2009, the entire contents of each of which are incorporated herein by reference.
TECHNICAL FIELD
The
Pyrimidine compounds and their uses
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FIELD
Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof.
##STR00002##
The present invention also
Pyrimidine compounds and their uses
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FIELD
Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof.
##STR00002##
The present invention also
Heterocycles
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FIELD
Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly
Substituted heterocyclic compounds and methods of use
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BACKGROUND OF THE INVENTION
The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the
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