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Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.

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To investigate the influence of obesity and obligatory bipedal walking on osteoarthritis (OA) development, 26-week-old C57BL/6 mice were divided into two groups and obesity was induced in one group with a 60% fat diet. After 8 weeks, mice from each group were again divided into two groups and

Effect of a hypocaloric diet with a commercial formula in weight loss and quality of life in obese patients with chronic osteoarthritis.

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BACKGROUND The aim of our study was to evaluate in patients with obesity and chronic osteoarthritis the impact on quality of life and metabolic control of a dietary intervention with a hypocaloric commercial formula. METHODS A sample of 55 obese patients with chronic osteoarthritis was enrolled. The

Delayed gadolinium-enhanced MRI of menisci and cartilage (dGEMRIM/dGEMRIC) in obese patients with knee osteoarthritis: Cross-sectional study of 85 obese patients with intra-articular administered gadolinium contrast.

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BACKGROUND Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). OBJECTIVE To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci

Obesity and load-induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma

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Osteoarthritis is increasingly viewed as a heterogeneous disease with multiple phenotypic subgroups. Obesity enhances joint degeneration in mouse models of posttraumatic osteoarthritis (PTOA). Most models of PTOA involve damage to surrounding tissues caused by surgery/fracture; it is unclear if

How to treat osteoarthritis in obese patients?

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The close association between osteoarthritis (OA) and obesity is well established. The concomitant increasing prevalence of the two diseases has major health, social and economic consequences. However, to date there is no specific recommendation for the medical management of obese patients with OA.

A comparison of obesity related adipokine concentrations in knee and shoulder osteoarthritis patients.

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OBJECTIVE The ratio between the serum and knee synovial fluid (SF) adipokine level has been correlated to osteoarthritis (OA) severity. No study has examined the relative concentration of adipokines in shoulder OA. However, in this study, we document serum and SF concentrations, and serum/SF ratios,

No association of the single nucleotide polymorphism rs8044769 in the fat mass and obesity-associated gene with knee osteoarthritis risk and body mass index: A population-based study in China.

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OBJECTIVE Previous genome-wide association studies (GWAS) have reported significant association of the single nucleotide polymorphism (SNP) rs8044769 in the fat mass and obesity-associated gene (FTO) with osteoarthritis (OA) risk in European populations. However, these findings have not been

An update on the science and therapy of obesity and its relationship to osteoarthritis.

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Obesity and osteoarthritis are two commonly encountered clinical problems that can lead to significant physical and emotional disability. This report examines the association between obesity and osteoarthritis, and discusses potential mechanisms by which obesity influences osteoarthritis. Special

[THE RELATIONSHIP BETWEEN OVERWEIGHT, OBESITY AND KNEE OSTEOARTHRITIS].

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BACKGROUND The prevalence of overweight and obesity in the western world is growing, and with it there is a growing number of patients with osteoarthritis, a condition that leads to pain and disability. The association between body weight and osteoarthritis is mediated by both mechanical and humeral

The interaction between obesity and RAGE polymorphisms on the risk of knee osteoarthritis in Chinese population.

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BACKGROUND The receptor for advanced glycation end products (RAGE) has been reported to relate to osteoarthritis (OA), however, the role of RAGE genetic variants in OA remains unknown. METHODS A total of 233 patients with primary knee OA and 255 healthy volunteer were recruited. Three RAGE gene

A New Perspective on the Relation Between Obesity and Knee Osteoarthritis: Omentin.

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Knee osteoarthritis (KOA) is defined as a chronic degenerative joint disease. Obesity is a significant risk factor for KOA. Omentin is an adipose tissue-induced adipokine. The aim of the present study was to investigate the correlation between obesity and serum omentin levels in

What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies.

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OBJECTIVE To summarize the overall relative risk of knee osteoarthritis (OA) associated with body mass index, and to estimate the potential risk reduction due to the control of this risk factor. METHODS Six electronic databases were searched up to July 2010. Relative risk was estimated using odds

Tranexamic acid reduces intraoperative occult blood loss and tourniquet time in obese knee osteoarthritis patients undergoing total knee arthroplasty: a prospective cohort study.

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UNASSIGNED Obesity can result in increased blood loss, which is correlated with poor prognosis in total knee arthroplasty (TKA). Clinical application of tranexamic acid is effective in reducing blood loss in TKA. However, most previous studies focused on the effect of tranexamic acid in the whole

Influence of obesity on the development of osteoarthritis of the hip: a systematic review.

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OBJECTIVE To evaluate the evidence for the influence of obesity as a risk factor for the occurrence of osteoarthritis (OA) of the hip. METHODS A bibliographical search of Medline, EMBASE and the Cochrane library until April 2000 was carried out. Articles describing studies of the relationship

Functionality in Middle-Aged and Older Overweight and Obese Individuals with Knee Osteoarthritis.

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Patients with knee osteoarthritis (OA) suffer from immobility and pain. The objective of this cross-sectional study was to investigate the relationship between pain and functionality in middle-aged and older overweight and obese individuals with mild-to-moderate knee OA. Overall pattern, physical

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