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10 полученные результаты
[The effects of long-term application of L-arginine on K+ channel in pulmonary artery smooth muscle cells from rats exposed to chronic hypoxia].
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OBJECTIVE
To investigate the effects of long-term application of L-arginine (L-Arg) on K(+) channel in pulmonary artery smooth muscle cells (PASMC) from rats exposed to chronic hypoxia.
METHODS
Male Wistar rats were randomly divided into three groups: group A (control group), group B (chronic
Pulmonary hypertension in rats with papain emphysema.
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Lung emphysema was produced in 80 rats by tracheal chronic constriction and repeated instillations of 0.1% papain solution intratracheally. 17 animals survived 90 days of the experiment; a complete examination was performed on 14 experimental and 11 control animals. 9 rats of the experimental group
[Effect of papain and levamisole on the body's immunological indices and oxidation-reduction processes in experimental sensitization].
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The effect of papain on sensitized animals was evident from activation of oxidation processes in the liver and adrenal glands, increased ability of the host to develop cellular immunity reactions, a moderate decrease in the level of humoral antibodies and inactivation of the monooxygenase system of
Hypoxia in fibroblast cultures. 2. Influence of pH on the distribution pattern of acid mucopolysaccharides.
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Secondary cultures of embryonic rat fibroblasts [NEUPERT et al., Exp. Path. 7, 19-28 (1972)] were cultured in 21% and 5% O2 concentration at pH 6.6 and 7.4 for 6 or 8 days. The acid mucopolysaccharides were isolated and fractionated by alcohol precipitation, papain digestion, CPC-precipitation and
Effects of nitrendipine and hypoxia on pulmonary vascular resistance in experimental emphysema.
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We evaluated the hemodynamic effects of nitrendipine, a dihydropyridine Ca2+ channel blocker, and hypoxia in intact dogs with emphysema produced by treatments with aerosolized papain. We also determined the effects of emphysema, chronic Ca2+ channel blocker treatment, and acute hypoxia on the
Impaired angiotensin conversion and bradykinin clearance in experimental canine pulmonary emphysema.
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Chronic hypoxic lung diseases are associated with abnormal blood pressure regulation. Because the lung is the principal site of angiotensin conversion and because hypoxia decreases converting enzyme activity, we examined whether angiotensin converting enzyme activity was impaired in lung disease. 12
[Effect of endothelin-1 on voltage-gated K+ current in the pulmonary artery smooth muscle cells of chronic hypoxic rats].
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OBJECTIVE
To investigate the effect of endothelin-1 (ET-1) on voltage-gated K+ current in the pulmonary artery smooth muscle cells (PASMCs) of chronic hypoxic rats.
METHODS
Twelve male Wistar rats matched with age and body weight were randomly divided into control and chronic hypoxic groups. Single
Increased left ventricular stiffness impairs filling in dogs with pulmonary emphysema in respiratory failure.
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In a chronic canine model of pulmonary emphysema, we studied the interaction between left ventricular (LV) mechanics and pulmonary disease during severe hypoxemia. The hypoxemia was similar to that which may occur during a severe exacerbation of chronic obstructive lung disease. In six dogs with
Cor pulmonale in experimental lung emphysema. II. An ultrastructure of myocardium.
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Development of ultrastructural changes in the hearts of rats with experimental lung emphysema, induced by proteolytic enzyme--papain, has been analysed. Simultaneous development of changes in the right ventricle muscle and in the subendocardial layer of the heart left ventricle myocardium was
Changes of myocardial capillary density in progression of experimental lung emphysema.
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A morphometrical analysis of changes in the heart of rats with experimental lung emphysema due to single intratracheal administration of papain solution has been done. Special attention has been paid to quantitative changes of capillaries and to the cardiomyocyte diameter in respective regions of
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